C21, C22 pregnane glycosides and cytotoxic C27 spriostanol steroids from Asparagus cochinchinesis

被引：8
|
作者：
Zhu, Guo-Lei [1 ,2 ]
Hao, Qian [2 ]
Xing, Liu [2 ]
Yang, Xiao-Qin [1 ]
Xie, Si-Da [1 ]
Zhao, Ping [1 ]
Li, Hai-Zhou [2 ]
机构：
[1] Southwest Forestry Univ, Key Lab, State Forestry Adm Highly Efficient Utilizat Fore, Kunming 650224, Yunnan, Peoples R China
[2] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Yunnan, Peoples R China
来源：
STEROIDS | 2021年 / 172卷
基金：
中国国家自然科学基金;
关键词：
Asparagus cochinchinensis; C-21 pregnane glycosides; C-22 pregnane glycosides; Cytotoxic steroids; SAPONINS; CONSTITUENTS; APOPTOSIS; ROOTS;
D O I：
10.1016/j.steroids.2021.108874
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A preliminary chemical investigation on 70% MeOH extract of the roots of Asparagus cochinchinensis resulted in the isolation of nine steroids. These isolates comprised of four new C-21 (1-4) and one new pregnane (5) glycosides, and four known C-27 (6-9) spirostanol steroids. Their structures were identified via analysis of the spectroscopic data and the results of hydrolytic cleavage. The cytotoxic activities of the compounds were tested toward the human tumor cell line Hela (cervical cancer), and compounds 7 and 8 displayed moderate activity with IC50 values of 35.5 and 39.6 mu M, respectively.
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页数：6
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