Relationship between the C-13-NMR chemical shift and the carcinogenic activity of benz[a]anthracenes

被引：0

作者：

Sakamoto, Y ^{[1
]}

Aoki, T ^{[1
]}

Ohshima, S ^{[1
]}

机构：

[1] TOHO UNIV, DEPT BIOMOLEC SCI, FUNABASHI, CHIBA 274, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1996年 / 44卷 / 02期

关键词：

7,12-dimethylbenz[a]anthracene; C-13-NMR; chemical shift; proton HOHAHA; C-13-H-1; HOHAHA; carcinogenicity;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A thorough NMR spectroscopic investigation was made on 7,12-dimethylbenz[a] anthracene (1) and the H-1- and C-13-NMR spectra were completely assigned, We compared the C-13-NMR chemical shifts (delta) of three benz[a]anthracenes, including compound 1, whose carcinogenicities vary largely, and investigated the relationship of the delta and carcinogenicity. It was found that the delta values at the Cl, C2, and C6 positions differed significantly between the carcinogenic and noncarcinogenic compounds.

引用

页码：424 / 428

页数：5

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