A highly efficient group-assisted purification method for the synthesis of poly-functionalized pyrimidin-5-yl-pyrroles via one-pot four-component domino reaction

被引：19
|
作者：
Dommaraju, Yuvaraj [1 ]
Prajapati, Dipak [1 ]
机构：
[1] CSIR North East Inst Sci & Technol, Div Med Chem, Jorhat 785006, Assam, India
来源：
MOLECULAR DIVERSITY | 2015年 / 19卷 / 01期
关键词：
Multicomponent reactions; Pyrrole; Pyrimidine; Chromatography; GAP chemistry; Green; sustainable chemistry; MCRs; CATALYTIC STRECKER REACTION; POLYSUBSTITUTED PYRROLES; MULTICOMPONENT REACTIONS; IMINE CHEMISTRY; ANALOGS; ET2ALCN; DESIGN;
D O I：
10.1007/s11030-014-9547-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A highly efficient, catalyst-free group-assisted purification chemical protocol for the construction of pyrimidine containing poly-functionalized pyrroles from a four-component domino reaction of acyclic-1,3-dicarbonyls or electron deficient alkynes, aromatic amines, barbituric acid and arylglyoxal hydrates under mild reaction conditions has been developed. The prominent features of the present protocol are environmentally benign, mild reaction conditions, atom economy, no column chromatography separation, easy isolation of products and excellent yields.
引用
收藏
页码：173 / 187
页数：15
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