Isolation and Structure Elucidation of Cembranoids from a Dongsha Atoll Soft Coral Sarcophyton stellatum

被引：24
|
作者：
Ahmed, Atallah F. [1 ,2 ]
Chen, Yi-Wei [1 ]
Huang, Chiung-Yao [1 ]
Tseng, Yen-Ju [1 ]
Lin, Chi-Chen [3 ]
Dai, Chang-Feng [4 ]
Wu, Yang-Chang [5 ]
Sheu, Jyh-Horng [1 ,5 ,6 ,7 ]
机构：
[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan
[2] King Saud Univ, Dept Pharmacognosy, Coll Pharm, Riyadh 11451, Saudi Arabia
[3] Natl Chung Hsing Univ, Inst Biomed Sci, Taichung 402, Taiwan
[4] Natl Taiwan Univ, Inst Oceanog, Taipei 112, Taiwan
[5] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan
[6] Natl Sun Yat Sen Univ, Frontier Ctr Ocean Sci & Technol, Kaohsiung 804, Taiwan
[7] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan
来源：
MARINE DRUGS | 2018年 / 16卷 / 06期
关键词：
soft coral; Sarcophyton stellatum; cembranoid; cytotoxic activity; anti-inflammatory activity; ORAL-CANCER CELLS; NATURAL-PRODUCTS; GLAUCUM; CRASSOCAULE; TERPENES; CYCLOOXYGENASE-2; BISCEMBRANOIDS; DITERPENES; EHRENBERGI; LACTONE;
D O I：
10.3390/md16060210
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Six new polyoxygenated cembrane-based diterpenoids, stellatumolides A-C (1-3), stellatumonins A and B (4 and 5), and stellatumonone (6), were isolated together with ten known related compounds (7-16) from the ethyl acetate (EtOAc) extract of soft coral Sarcophyton stellatum. The structures of the new compounds were established by extensive spectroscopic analyses, including 1D and 2D nuclear magnetic resonance (NMR) spectroscopy and data comparison with related structures. Compounds 8 and 14 were isolated from a natural source for the first time. The isolated metabolites were shown to be not cytotoxic against a limited panel of cancer cells. Compound 9 showed anti-inflammatory activity by reducing the expression of proinflammatory cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) proteins in lipopolysaccharide (LPS)-stimulated mouse leukaemic monocyte macrophage (RAW 264.7) cells.
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页数：15
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