Innate immunity and epigenetic plasticity in cellular reprogramming

被引：7

作者：

Cooke, John P. ^{[1
]}

Sayed, Nazish ^{[1
]}

Lee, Jieun ^{[2
]}

Wong, Wing Tak ^{[1
]}

机构：

[1] Houston Methodist Res Inst, Ctr Cardiovasc Regenerat, Houston, TX 77030 USA

[2] Stanford Univ, Dept Med, Stanford, CA 94305 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2014年 / 28卷

关键词：

PLURIPOTENT STEM-CELLS; ACTIVATION; MECHANISMS;

D O I：

10.1016/j.gde.2014.11.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Somatic cells can be reprogrammed to express the features of pluripotent cells, in that they can be differentiated into all three germ layers, and that they have the ability to replicate indefinitely. Recent studies suggest that the efficient induction of pluripotency requires the activation of innate immunity.

引用

页码：89 / 91

页数：3

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