siRNA targeting of mitochondrial thymidine kinase 2 (TK2) sensitizes cancer cells to gemcitabine and increases mitochondrial toxicity

被引：0
|
作者：
Di Cresce, C. [1 ]
Ferguson, P. [2 ]
Figueredo, R. [2 ]
Rytelewski, M. [1 ]
Vareki, S. Maleki [1 ]
Vincent, M. D. [1 ]
Koropatnick, J. [1 ]
机构：
[1] Univ Western Ontario, London, ON, Canada
[2] London Reg Canc Ctr, Canc Res Labs, London, ON N6A 4L6, Canada
来源：
EUROPEAN JOURNAL OF CANCER | 2014年 / 50卷
关键词：
D O I：
10.1016/S0959-8049(14)70175-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
49
引用
收藏
页码：21 / 21
页数：1
相关论文
共 50 条
  • [21] Structure, physiological role, and specific inhibitors of human thymidine kinase 2 (TK2):: Present and future
    Perez-Perez, Maria-Jesus
    Priego, Eva-Maria
    Hernandez, Ana-Isabel
    Familiar, Olga
    Camarasa, Maria-Jose
    Negri, Ana
    Gago, Federico
    Balzarini, Jan
    MEDICINAL RESEARCH REVIEWS, 2008, 28 (05) : 797 - 820
  • [22] Mitochondrial depletion syndrome TK2 deficiency can be treated with oral deoxynucleosides
    Topaloglu, H.
    Eser, G.
    Yuksel, B.
    NEUROMUSCULAR DISORDERS, 2023, 33 : S184 - S184
  • [23] Mitochondrial DNA depletion in single fibers in a patient with novel TK2 mutations
    Roos, S.
    Lindgren, U.
    Ehrstedt, C.
    Moslemi, A. R.
    Oldfors, A.
    NEUROMUSCULAR DISORDERS, 2014, 24 (08) : 713 - 720
  • [24] Mitochondrial DNA depletion in single fibers in a patient with novel TK2 mutations
    Roos, S.
    Lindgren, U.
    Ehrstedt, C.
    Moslemi, A. R.
    Oldfors, A.
    NEUROMUSCULAR DISORDERS, 2014, 24 (9-10) : 865 - 865
  • [25] Substrate/inhibitor specificities of human deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2)
    Kierdaszuk, B
    Krawiec, K
    Kazimierczuk, Z
    Jacobsson, U
    Johansson, NG
    Munch-Petersen, B
    Eriksson, S
    Shugar, D
    PURINE AND PYRIMIDINE METABOLISM IN MAN IX, 1998, 431 : 623 - 627
  • [26] Infantile TK2 Deficiency Causing Mitochondrial Encephalomyopathy With Migrating Focal Seizures
    Bergonzini, Luca
    Carli, Sara
    Pelle, Silvia
    Pettenuzzo, Ilaria
    Bonetti, Silvia
    Santi, Erika
    Visconti, Caterina
    Maffei, Monica
    Sheremet, Marta
    Lamantea, Eleonora
    Marsala, Andrea
    Klub, Olena
    Gentile, Valentina
    Cordelli, Duccio Maria
    Garone, Caterina
    NEUROLOGY, 2025, 104 (07)
  • [27] Tracking cellular stress with labeled FMAU reflects changes in mitochondrial TK2
    Tehrani, Omid S.
    Douglas, Kirk A.
    Lawhorn-Crews, Jawana M.
    Shields, Anthony F.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2008, 35 (08) : 1480 - 1488
  • [28] From M-tuberculosis thymidine monophosphate kinase (TMPKmt) inhibitors towards mitochondrial thymidine kinase (TK-2) inhibitors
    Van Calenbergh, Serge
    Van Daele, Ineke
    Van Poecke, Sara
    Froeyen, Matheus
    Lehmann, Helene Munier
    Balzarini, Jan
    CHEMISTRY OF NUCLEIC ACID COMPONENTS, 2008, 10 : 87 - 93
  • [29] N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors
    Hernandez, Ana-Isabel
    Familiar, Olga
    Negri, Ana
    Rodriguez-Barrios, Fatima
    Gago, Federico
    Karlsson, Anna
    Camarasa, Maria-Jose
    Balzarini, Jan
    Perez-Perez, Maria-Jesus
    JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (26) : 7766 - 7773
  • [30] A retrospective study of the combination of pyrimidine nucleos(t)ides in patients with thymidine kinase 2 (TK2) deficiency
    Quan, J.
    Dominguez-Gonzalez, C.
    Paradas, C.
    Madruga-Garrido, M.
    Nascimento Osorio, A.
    Munell, F.
    Mandel, H.
    Falik-Zaccai, T.
    Ginsberg, M.
    Tal, G.
    Garone, C.
    Barca, E.
    Moors, T.
    Hirano, M.
    NEUROMUSCULAR DISORDERS, 2019, 29 : S58 - S58
12345