siRNA targeting of mitochondrial thymidine kinase 2 (TK2) sensitizes cancer cells to gemcitabine and increases mitochondrial toxicity

被引：0
|
作者：
Di Cresce, C. [1 ]
Ferguson, P. [2 ]
Figueredo, R. [2 ]
Rytelewski, M. [1 ]
Vareki, S. Maleki [1 ]
Vincent, M. D. [1 ]
Koropatnick, J. [1 ]
机构：
[1] Univ Western Ontario, London, ON, Canada
[2] London Reg Canc Ctr, Canc Res Labs, London, ON N6A 4L6, Canada
来源：
EUROPEAN JOURNAL OF CANCER | 2014年 / 50卷
关键词：
D O I：
10.1016/S0959-8049(14)70175-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
49
引用
收藏
页码：21 / 21
页数：1
相关论文
共 50 条
  • [1] siRNA knockdown of mitochondrial thymidine kinase 2 (TK2) sensitizes human tumor cells to gemcitabine
    Di Cresce, Christine
    Figueredo, Rene
    Rytelewski, Mateusz
    Vareki, Saman Maleki
    Way, Colin
    Ferguson, Peter J.
    Vincent, Mark D.
    Koropatnick, James
    ONCOTARGET, 2015, 6 (26) : 22397 - 22409
  • [2] Targeted transgenic overexpression of mitochondrial thymidine kinase (TK2) alters mitochondrial DNA (mtDNA) and mitochondrial polypeptide abundance - Transgenic TK2, mtDNA, and antiretrovirals
    Hosseini, Seyed H.
    Kohler, James J.
    Haase, Chad P.
    Tioleco, Nina
    Stuart, Tami
    Keebaugh, Erin
    Ludaway, Tomika
    Russ, Rodney
    Green, Elgin
    Long, Robert
    Wang, Liya
    Eriksson, Staffan
    Lewis, William
    AMERICAN JOURNAL OF PATHOLOGY, 2007, 170 (03): : 865 - 874
  • [3] Transgenic expression of mitochondrial thymidine kinase isoform (TK2) increases mitochondrial DNA (mtDNA) and subsequent myocardial dysfunction following HAART
    Hosseini, S
    Kohler, J
    Haase, C
    Ludaway, T
    Russ, R
    McNaught, J
    Tioleco, N
    Keebaugh, E
    Lewis, W
    FASEB JOURNAL, 2006, 20 (04): : A639 - A639
  • [4] Novel mutations in the thymidine kinase 2 gene (TK2) associated with fatal mitochondrial myopathy and mitochondrial DNA depletion
    Tulinius, M
    Moslemi, AR
    Darin, N
    Holme, E
    Oldfors, A
    NEUROMUSCULAR DISORDERS, 2005, 15 (06) : 412 - 415
  • [5] Mitochondrial myopathy caused by thymidine kinase 2 (TK2) mutation mimics congenital muscular dystrophy
    Isohanni, P.
    Marjavaara, S.
    Paetau, A.
    Herva, R.
    Suomalainen, A.
    Pihko, H.
    NEUROMUSCULAR DISORDERS, 2007, 17 (9-10) : 770 - 770
  • [6] mtDNA depletion myopathy: elucidation of the tissue specificity in the mitochondrial thymidine kinase (TK2) deficiency
    Saada, A
    Shaag, A
    Elpeleg, O
    MOLECULAR GENETICS AND METABOLISM, 2003, 79 (01) : 1 - 5
  • [7] Novel mutations in thymidine kinase-2 (TK2) associated with fatal mitochondrial myopathy and mtDNA depletion
    Oldfors, A
    Moslemi, AR
    Tulinius, M
    Darin, N
    Holme, E
    NEUROMUSCULAR DISORDERS, 2004, 14 (8-9) : 568 - 568
  • [8] 5-bromovinyl 2'-deoxyuridine phosphorylation by mitochondrial and cytosolic thymidine kinase (TK2 and TK1) and its use in selective measurement of TK2 activity in crude extracts
    Wang, Liya
    Eriksson, Staffan
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2008, 27 (6-7): : 858 - 862
  • [9] Thymidine phosphorylation by transgene expression of the Drosophila melanogaster nucleoside kinase rescues the pathology of mitochondrial TK2 deficiency
    Krishnan, Shuba
    Zhou, Xiaoshan
    Paredes, Joao
    Karlsson, Anna
    MITOCHONDRION, 2012, 12 (05) : 555 - 555
  • [10] The role of mitochondrial dNTP levels in cells with reduced TK2 activity
    Desler, C.
    Munch-Petersen, B.
    Rasmussen, L. J.
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2006, 25 (9-11): : 1171 - 1175
12345