One-pot four-component reaction for convenient synthesis of functionalized 1-benzamidospiro[indoline-3,4′-pyridines]

被引：8
|
作者：
Wang, Chao [1 ]
Jiang, Yan-Hong [1 ]
Yan, Chao-Guo [1 ]
机构：
[1] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Peoples R China
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 10卷
基金：
中国国家自然科学基金;
关键词：
acetylenedicarboxylate; benzohydrazide; 1,4-dihydropyridine; multicomponent reaction; one-pot reaction; spiro[indoline-3,4'-pyridine; 1,4-DIPOLAR CYCLOADDITIONS; MULTICOMPONENT REACTIONS; FACILE SYNTHESIS; CONSTRUCTION; ARYLAMINES; STRATEGIES; ISATINS; SPIROOXINDOLES;
D O I：
10.3762/bjoc.10.281
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The one-pot four-component reaction of benzohydrazide (2-picolinohydrazide), acetylenedicarboxylate, isatins and malononitrile (ethyl cyanoacetate) with triethylamine as base catalyst afforded functionalized 1-benzamidospiro[indoline-3,4'-pyridines] in good yields. H-1 NMR spectra indicated that an equilibrium of cis/trans-conformations exist in the obtained products.
引用
收藏
页码：2671 / 2676
页数：6
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