Cardioprotective Effect of Opioids, Derivatives of Amide N-Methyl-2-(Pirrolidin-1-yl)Cyclohexyl-1-Amine, under Conditions of Ischemia/Reperfusion of the Heart

被引：0
|
作者：
Mukhomedzyanov, A., V [1 ]
Zhuk, V. V. [2 ]
Maslov, L. N. [1 ]
Shipunov, A., I [2 ]
Andrienko, O. S. [3 ]
Gadirov, R. M. [4 ]
机构：
[1] Russian Acad Sci, Tomsk Natl Res Med Ctr, Cardiol Res Inst, Tomsk, Russia
[2] MedContrast Synth Co, Tomsk, Russia
[3] Russian Acad Sci, Inst Atmospher Opt, Siberian Div, Tomsk, Russia
[4] Natl Res Tomsk State Univ, Tomsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2021年 / 170卷 / 06期
关键词：
heart; reperfusion; opioids; postconditioning; ACUTE MYOCARDIAL-INFARCTION; REPERFUSION; ACTIVATION; RECEPTORS;
D O I：
10.1007/s10517-021-05138-y
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We performed a comparative analysis of infarction-limiting activity of analogues of opioid receptor agonist U-50488 under conditions of heart reperfusion in rats. Derivatives of amide N-methyl-2-(pyrrolidin-1-yl)cyclohexyl-1-amine were administered 5 min before reperfusion in a dose of 1 mg/kg, derivative II (opicor) was additionally used in a dose of 2 mg/kg. In a dose of 1 mg/kg, all derivatives of opioid U-50488 were ineffective and produced no infarction-limiting effect. Opicor in a dose of 2 mg/kg reduced the infarction size/area at risk ratio and improved the contractility parameters of the isolated heart. Opioid receptor antagonist naltrexone (5 mg/kg) abolished the infarction-limiting effect of opicor. Hence, the infarction-reducing effect of opicor is associated with activation of opioid receptors. We also demonstrated that the opioid (opicor) can improve cardiac contractility during the reperfusion period.
引用
收藏
页码：710 / 713
页数：4
相关论文
共 16 条
  • [1] Cardioprotective Effect of Opioids, Derivatives of Amide N-Methyl-2-(Pirrolidin-1-yl)Cyclohexyl-1-Amine, under Conditions of Ischemia/Reperfusion of the Heart
    A. V. Mukhomedzyanov
    V. V. Zhuk
    L. N. Maslov
    A. I. Shipunov
    O. S. Andrienko
    R. M. Gadirov
    Bulletin of Experimental Biology and Medicine, 2021, 170 : 710 - 713
  • [2] Synthesis of N-((2-Substituted Phenyl)-4, 5-Diphenyl-1H-Imidazol-1yl)(Phenyl)Methyl) substituted amine derivatives, spectral characterization and their pharmacological evaluation
    Shalini, Kumari
    Kumar, Nitin
    Sharma, Pramod Kumar
    BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, 2011, 1 (05): : 184 - 190
  • [3] An efficient and green synthesis of highly functionalized N-methyl-2-nitro-aryl-1H-benzo[f]lchromen-3-amine derivatives under catalyst-free conditions
    Reddy, Mudumala Veeranarayana
    Reddy, Guda Dinneswara
    Kim, Jong Tae
    Jeong, Yeon Tae
    TETRAHEDRON, 2016, 72 (41) : 6484 - 6491
  • [4] Synthesis and antimycobacterial screening of new N-(4-(5-aryl-3-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-pyrazol-1-yl)phenyl)-4-amide derivatives
    Nayak, Nagabhushana
    Ramprasad, Jurupula
    Dalimba, Udayakumar
    Yogeeswari, Perumal
    Sriram, Dharmarajan
    CHINESE CHEMICAL LETTERS, 2016, 27 (03) : 365 - 369
  • [5] Synthesis and antimycobacterial screening of new N-(4-(5-aryl-3-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-pyrazol-1-yl)phenyl)-4-amide derivatives
    Nagabhushana Nayak
    Jurupula Ramprasad
    Udayakumar Dalimba
    Perumal Yogeeswari
    Dharmarajan Sriram
    Chinese Chemical Letters, 2016, 27 (03) : 365 - 369
  • [6] FeF3-mediated tandem annulation: a highly efficient one-pot synthesis of functionalized N-methyl-3-nitro-4H-pyrimido [2, 1-b] [1, 3] benzothiazole-2-amine derivatives under neat conditions
    Amol Balu Atar
    Eunbi Han
    Jongmin Kang
    Molecular Diversity, 2020, 24 : 443 - 453
  • [7] Creatine Is a Scavenger for Methylglyoxal under Physiological Conditions via Formation of N-(4-Methyl-5-oxo-1-imidazolin-2-yl)sarcosine (MG-HCr)
    Loebner, Juergen
    Degen, Julia
    Henle, Thomas
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2015, 63 (08) : 2249 - 2256
  • [8] Synthesis and Characterization of Carbonyl Group-6-Metal Derivatives with Ligand N,N-Bis(diphenylphosphino)naphthalen-1-amine (=N-(Diphenylphosphino)-N-naphthalen-1-yl-P,P-diphenylphosphinous Amide). Molecular Structure of cis-Tetracarbonyl[N-(diphenylphosphino-P)-N-naphthalen-1-yl-P,P-diphenylphosphinous amide-P]molybdenum (cis-[Mo(CO)4{C10H7-1-N(PPh2)2}])
    Al-Masri, Harbi Tomah
    Mohamed, Beshir M.
    Moussa, Ziad
    Alkordi, Mohamed H.
    HELVETICA CHIMICA ACTA, 2013, 96 (04) : 738 - 746
  • [9] FeF3-mediated tandem annulation: a highly efficient one-pot synthesis of functionalized N-methyl-3-nitro-4H-pyrimido [2, 1-b] [1,3] benzothiazole-2-amine derivatives under neat conditions
    Atar, Amol Balu
    Han, Eunbi
    Kang, Jongmin
    MOLECULAR DIVERSITY, 2020, 24 (02) : 443 - 453
  • [10] Theoretical Investigation on Solvents Effect in Molecular Structure (TD-DFT, MEP, HOMO-LUMO), Topological Analysis and Molecular Docking Studies of N-(5-((4-Ethylpiperazin-1-yl)Methyl)Pyridin-2-yl)-5-Fluoro-4-(4-Fluoro-1-Isopropyl-2-Methyl-1H-Benzo[d] Imidazol-6-yl) Pyrimidin-2-Amine
    Elangovan, N.
    Sowrirajan, S.
    Arumugam, Natarajan
    Rajeswari, B.
    Mathew, Shanty
    Priya, C. Geetha
    Venkatraman, B. R.
    Mahalingam, Sakkarapalayam M.
    POLYCYCLIC AROMATIC COMPOUNDS, 2024, 44 (07) : 4467 - 4490
12