Engineering a Material Surface for Drug Delivery and Imaging using Layer-by-Layer Assembly of Functionalized Nanoparticles

被引：27

作者：

Soike, Thomas ^{[1
,2
]}

Streff, Amanda K. ^{[1
,2
]}

Guan, Chenxia ^{[1
,2
]}

Ortega, Ryan ^{[1
]}

Tantawy, Mohammed ^{[1
,4
]}

Pino, Christopher ^{[1
]}

Shastri, V. Prasad ^{[1
,2
,3
]}

机构：

[1] Univ Freiburg, Inst Macromol Chem, D-79104 Freiburg, Germany

[2] Vanderbilt Univ, Dept Biomed Engn, Nashville, TN 37232 USA

[3] Univ Freiburg, Bioss Ctr Biol Signalling Studies, D-79104 Freiburg, Germany

[4] Vanderbilt Inst Imaging Sci, Dept Radiol, Nashville, TN 37232 USA

来源：

ADVANCED MATERIALS | 2010年 / 22卷 / 12期

关键词：

ELUTING STENTS; FILMS; DEPOSITION; RELEASE; MULTILAYERS; ADSORPTION; CARDIOLOGY; PARTICLES; FRONTIERS; EROSION;

D O I：

10.1002/adma.200903069

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Layer-by-layer (LBL) assembly of functionalized nanoparticles (FNPs) within a polyelectrolyte network is described (see image). The LBL-NP-assembly-based modification can be used to engineer surfaces with multiple functions such as controlled (multiple-) drug release with distinct release kinetics and enhanced contrast in clinical imaging modalities. This novel surface modification strategy is expected to accelerate the development of bioresponsive coatings for implantable biomedical devices.

引用

页码：1392 / +

页数：7

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