Metal-free oxidative cross-dehydrogenative coupling of quinones with benzylic C(sp3)-H bonds

被引：16

作者：

Dong, Yu ^{[1
,2
]}

Yang, Jian ^{[1
,2
]}

He, Shuai ^{[3
]}

Shi, Zhi-Chuan ^{[3
]}

Wang, Yu ^{[4
]}

Zhang, Xiao-Mei ^{[1
]}

Wang, Ji-Yu ^{[1
]}

机构：

[1] Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Sichuan, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Southwest Minzu Univ, Chengdu 610041, Sichuan, Peoples R China

[4] Guizhou Educ Univ, Guiyang 550018, Guizhou, Peoples R China

来源：

RSC ADVANCES | 2019年 / 9卷 / 47期

关键词：

C-C BOND; ALPHA-ARYLATION; H BONDS; DERIVATIVES; ACTIVATION; STRATEGY; ETHERS; ARYL; CASCADE; 1,4-NAPHTHOQUINONES;

D O I：

10.1039/c9ra05678e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A metal-free cross-dehydrogenative coupling of quinones with toluene derivatives has been established. A series of quinones were subjected to reaction with toluene derivatives in the presence of di-tertbutyl peroxide (DTBP) for direct synthesis of benzylquinones. The method exhibits good functional group tolerance, and desired products were obtained in moderate to good yields. Meanwhile, a radical pathway was proposed to describe the cross-dehydrogenative coupling of quinones with toluene derivatives.

引用

页码：27588 / 27592

页数：5

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