BENZIMIDAZOLE DERIVATIVES AS NOVEL SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS. A COMPUTATIONAL AND MUTAGENESIS STUDY OF LIGAND-RECEPTOR INTERACTION

被引:0
|
作者
Martin-Fontecha, Mar [1 ]
Benhamu, Bellinda [1 ]
de la Fuente, Tania [1 ]
Sallander, Jessica [2 ]
Campillo, Mercedes [2 ]
Vazquez-Villa, Henar [2 ]
Pellisier, Lucie [3 ]
Claeysen, Sylvie [3 ]
Dumuis, Aline [3 ]
Pardo, Leonardo [2 ]
Lopez-Rodriguez, Maria L. [1 ]
机构
[1] Univ Complutense Madrid, Fac Ciencias Quim, Dept Quim Organ 1, E-28040 Madrid, Spain
[2] Univ Autonoma Barcelona, Unitat Bioestadist, Lab Med Computac, E-08913 Barcelona, Spain
[3] Univ Montpellier, CNRS, Inst Genom Fonct, Dept Neurobiol, F-34094 Montpellier, France
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:217 / 217
页数:1
相关论文
共 50 条
  • [31] 5-Cyclic Amine-3-arylsulfonylindazoles as Novel 5-HT6 Receptor Antagonists
    Haydar, Simon N.
    Yun, Heedong
    Andrae, Patrick M.
    Mattes, James
    Zhang, Jean
    Kramer, Angela
    Smith, Deborah L.
    Huselton, Christine
    Graf, Radka
    Aschmies, Suzan
    Schechter, Lee E.
    Comery, Thomas A.
    Robichaud, Albert J.
    JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (06) : 2521 - 2527
  • [32] Novel aryl sulfonamides as potent, selective and brain penetrant 5-HT6 receptor antagonists
    Nirogi, Ramakrishna
    Kambhampati, Ramasastry
    Shinde, Anil
    Daulatabad, Anand
    Badange, Rajeshkumar
    Gudla, Parandhama
    Shaik, Mohammad
    Balasubramaniam, Suresh
    Bejjanki, Bajibabu
    Gampa, Murlimohan
    Pamuleti, Narasimhareddy G.
    Bhatta, Venugopalarao
    Reballi, Veena
    Ahmad, Ishtiyaque
    Bhyrapuneni, Gopinadh
    Jayarajan, Pradeep
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 241
  • [33] 5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer’s disease
    Neil Upton
    Tsu Tshen Chuang
    Ann J. Hunter
    David J. Virley
    Neurotherapeutics, 2008, 5 : 458 - 469
  • [34] 5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease
    Upton, Neil
    Chuang, Tsu Tshen
    Hunter, Ann J.
    Virley, David J.
    NEUROTHERAPEUTICS, 2008, 5 (03) : 458 - 469
  • [35] Novel aryl sulfonamides: A new chemical class of selective 5-HT6 receptor antagonists
    Shinde, Anil K.
    Daulatabad, Anand V.
    Gudla, Parandhama
    Reballi, Veena
    Rambabu, Namala
    Badange, Rajesh
    Kambhampati, Rama Sastry
    Nirogi, Ramakrishna
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 237
  • [36] Novel substituted piperazines: New chemical class of selective 5-HT6 receptor antagonists
    Shirsath, Vikas S.
    Deshpande, Amol D.
    Dwarampudi, Adi R.
    Bhatta, Venugopala Rao
    Bhosale, Sandeep B.
    Kota, Srinivasulu
    Kandikere, Vishwottam N.
    Kambhampati, Rama S.
    Nirogi, Ramakrishna V. S.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 231
  • [37] 5-Ht6 Receptor Antagonists. V. Structure – Activity Relationship of (4-Phenylsulfonyloxazol-5-yl)amines
    A. V. Ivachtchenko
    E. S. Golovina
    M. G. Kadieva
    O. D. Mitkin
    I. M. Okun
    Pharmaceutical Chemistry Journal, 2013, 46 : 639 - 646
  • [38] 5-HT6 Receptor antagonists. I. Screening of the library of various heterocyclic compounds containing an alkylsulfonyl moiety
    A. V. Ivachtchenko
    E. S. Golovina
    M. G. Kadieva
    O. D. Mitkin
    S. E. Tkachenko
    I. M. Okun
    Pharmaceutical Chemistry Journal, 2012, 46 : 274 - 284
  • [39] 5-HT6 Receptor antagonists. I. Screening of the library of various heterocyclic compounds containing an alkylsulfonyl moiety
    Ivachtchenko, A. V.
    Golovina, E. S.
    Kadieva, M. G.
    Mitkin, O. D.
    Tkachenko, S. E.
    Okun, I. M.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2012, 46 (05) : 274 - 284
  • [40] Dynamics and structural determinants of ligand recognition of the 5-HT6 receptor
    Márton Vass
    Balázs Jójárt
    Ferenc Bogár
    Gábor Paragi
    György M. Keserű
    Ákos Tarcsay
    Journal of Computer-Aided Molecular Design, 2015, 29 : 1137 - 1149