BENZIMIDAZOLE DERIVATIVES AS NOVEL SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS. A COMPUTATIONAL AND MUTAGENESIS STUDY OF LIGAND-RECEPTOR INTERACTION

被引:0
|
作者
Martin-Fontecha, Mar [1 ]
Benhamu, Bellinda [1 ]
de la Fuente, Tania [1 ]
Sallander, Jessica [2 ]
Campillo, Mercedes [2 ]
Vazquez-Villa, Henar [2 ]
Pellisier, Lucie [3 ]
Claeysen, Sylvie [3 ]
Dumuis, Aline [3 ]
Pardo, Leonardo [2 ]
Lopez-Rodriguez, Maria L. [1 ]
机构
[1] Univ Complutense Madrid, Fac Ciencias Quim, Dept Quim Organ 1, E-28040 Madrid, Spain
[2] Univ Autonoma Barcelona, Unitat Bioestadist, Lab Med Computac, E-08913 Barcelona, Spain
[3] Univ Montpellier, CNRS, Inst Genom Fonct, Dept Neurobiol, F-34094 Montpellier, France
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:217 / 217
页数:1
相关论文
共 50 条
  • [1] Benzimidazole Derivatives as New Serotonin 5-HT6 Receptor Antagonists. Molecular Mechanisms of Receptor Inactivation
    de la Fuente, Tania
    Martin-Fontecha, Mar
    Sallander, Jessica
    Benhamu, Bellinda
    Campillo, Mercedes
    Medina, Rocio A.
    Pellissier, Lucie P.
    Claeysen, Sylvie
    Dumuis, Aline
    Pardo, Leonardo
    Lopez-Rodriguez, Maria L.
    JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (03) : 1357 - 1369
  • [2] Potent and selective 5-HT6 receptor antagonists.
    Bromidge, SM
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1999, 218 : U971 - U971
  • [3] Identification of Novel Indanylsulfonamide Guanylhydrazones as Potent 5-HT6 Serotonin Receptor Antagonists
    Mesquida, Neus
    Lopez-Perez, Sara
    Dinares, Immaculada
    Frigola, Jordi
    Merce, Ramon
    Holenz, Joerg
    Perez, Raquel
    Burgueno, Javier
    Alcalde, Ermitas
    JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (19) : 6153 - 6157
  • [4] Novel 5-HT6 receptor antagonists for the treatment of obesity
    Shacham, S
    Marantz, Y
    Senderowitz, H
    Orbach, P
    Sharadendu, A
    Becker, O
    Noiman, S
    OBESITY RESEARCH, 2005, 13 : A192 - A192
  • [5] New Triazine Derivatives as Serotonin 5-HT6 Receptor Ligands
    Lazewska, Dorota
    Wiecek, Malgorzata
    Satala, Grzegorz
    Chalupnik, Paulina
    Zeslawska, Ewa
    Honkisz-Orzechowska, Ewelina
    Tarasek, Monika
    Latacz, Gniewomir
    Nitek, Wojciech
    Szymanska, Ewa
    Handzlik, Jadwiga
    MOLECULES, 2023, 28 (03):
  • [6] Serotonin 5-HT6 receptor antagonists for the treatment of Alzheimer's disease
    Geldenhuys, Werner J.
    Van der Schyf, Cornelis J.
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2008, 8 (12) : 1035 - 1048
  • [7] New serotonin 5-HT1a receptor antagonists.
    Oya, S
    Kung, MP
    Mu, M
    Kung, HF
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1998, 216 : U243 - U243
  • [8] Novel brain penetrant benzofuropiperidine 5-HT6 receptor antagonists
    Sundar, Babu G.
    Bailey, Thomas R.
    Dunn, Derek D.
    Bacon, Edward R.
    Salvino, Joseph M.
    Morton, George C.
    Aimone, Lisa D.
    Huang Zeqi
    Mathiasen, Joanne R.
    Dicamillo, Amy
    Huffman, Mark J.
    McKenna, Beth A.
    Kopec, Karla
    Lu, Lily D.
    Brown, Rebecca
    Qian, Jie
    Angeles, Thelma
    Connors, Thomas
    Spais, Chrysanthe
    Holskin, Beverly
    Galinis, Deborah
    Duzic, Emir
    Schaffhauser, Herve
    Rosse, Gerard C.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (01) : 120 - 123
  • [9] MOLECULAR AND PHARMACOLOGICAL PROPERTIES OF A NOVEL SEROTONIN RECEPTOR (5-HT6)
    TRAIFFORT, E
    RUAT, M
    ARRANG, JM
    LEURS, R
    DIAZ, G
    TARDIVELLACOMBE, J
    SCHWARTZ, JC
    JOURNAL OF NEUROCHEMISTRY, 1993, 61 : S89 - S89
  • [10] Potent and selective 5-HT6 receptor antagonists
    Bromidge, SM
    MEDICINAL CHEMISTRY INTO THE MILLENNIUM, 2001, (264): : 101 - 119