The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic

被引：5

作者：

Licordari, Roberto ^{[1
]}

Sticchi, Alessandro ^{[2
,3
,4
]}

Mancuso, Filippo ^{[1
]}

Caracciolo, Alessandro ^{[1
]}

Muscoli, Saverio ^{[5
]}

Iacovelli, Fortunato ^{[6
]}

Ruggiero, Rossella ^{[2
,7
]}

Scoccia, Alessandra ^{[2
,7
]}

Cammalleri, Valeria ^{[5
]}

Pavani, Marco ^{[8
]}

Loffi, Marco ^{[9
]}

Scordino, Domenico ^{[10
]}

Ferro, Jayme ^{[11
]}

Rognoni, Andrea ^{[12
]}

Buono, Andrea ^{[13
]}

Nava, Stefano ^{[14
]}

Albani, Stefano ^{[15
]}

Colaiori, Iginio ^{[16
]}

Zilio, Filippo ^{[17
]}

Borghesi, Marco ^{[17
]}

Regazzoni, Valentina ^{[9
]}

Benenati, Stefano ^{[18
]}

Pescetelli, Fabio ^{[18
]}

De Marzo, Vincenzo ^{[18
]}

Mannarini, Antonia ^{[6
]}

Spione, Francesco ^{[6
]}

Baldassarre, Doronzo ^{[8
]}

De Benedictis, Michele ^{[8
]}

Bonmassari, Roberto ^{[17
]}

Danzi, Gian Battista ^{[9
]}

Galli, Mario ^{[11
]}

Ielasi, Alfonso ^{[13
]}

Musumeci, Giuseppe ^{[15
]}

Tomai, Fabrizio ^{[10
]}

Pasceri, Vincenzo ^{[19
]}

Porto, Italo ^{[18
]}

Patti, Giuseppe ^{[12
]}

Campo, Gianluca ^{[7
]}

Colombo, Antonio ^{[2
]}

Micari, Antonio ^{[1
]}

Giannini, Francesco ^{[2
]}

Costa, Francesco ^{[1
]}

机构：

[1] Univ Messina, Dept Clin & Expt Med, Policlin G Martino, I-98124 Messina, Italy

[2] Maria Cecilia Hosp, GVM Care & Res, I-48033 Cotignola, Italy

[3] Ctr Lotta Contro Infarto CLI Fdn, I-00182 Rome, Italy

[4] St Camillus Int Univ Hlth Sci, Dept Cardiol, I-00131 Rome, Italy

[5] Tor Vergata Univ, Dept Cardiovasc Dis, I-00133 Rome, Italy

[6] Policlin Univ Hosp, Div Univ Cardiol, Cardiothorac Dept, I-072006 Bari, Italy

[7] Azienda Osped Univ Ferrara, Cardiovasc Inst, I-30010 Cona, Italy

[8] Osped Civile SS Annunziata, Dept Cardiol, I-12038 Savigliano, Italy

[9] Osped Cremona, Dept Cardiol, I-26100 Cremona, Italy

[10] Aurelia Hosp, Div Cardiol, I-00165 Rome, Italy

[11] Osped S Anna Como, ASST Lariana, Dipartimento Emergenza Rianimaz & Anestesia, UOSD Cardiol Lab Emodinam, I-22100 Como, Italy

[12] Azienda Osped Univ Maggiore della Carita, Dept Cardiol, I-28100 Novara, Italy

[13] Ist Clin St Ambrogio, Clin & Intervent Cardiol Unit, I-20149 Milan, Italy

[14] ASST Grande Osped Metropolitano Niguarda, Div Invas Cardiol, I-20162 Milan, Italy

[15] Mauriziano Hosp, Dept Cardiol, I-10128 Turin, Italy

[16] IRCCS Reggio Emilia, Azienda Unita Sanitaria Locale, I-42123 Reggio Emilia, Italy

[17] Osped Santa Chiara, UOC Cardiol, I-38121 Trento, Italy

[18] Osped Policlin San Martino IRCCS, Dipartimento CardioToracoVasc, I-16132 Genoa, Italy

[19] San Filippo Neri Roma, Dept Cardiol, I-00135 Rome, Italy

来源：

JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 10期

关键词：

acute coronary syndrome (ACS); COVID-19; myocardial infarction (MI); bleeding; in-hospital outcomes; ST-SEGMENT-ELEVATION; ACUTE MYOCARDIAL-INFARCTION; GUIDELINES; CARDIOLOGY; SOCIETY; MANAGEMENT; EVENTS; RISK;

D O I：

10.3390/jcm11102926

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The COVID-19 pandemic increased the complexity of the clinical management and pharmacological treatment of patients presenting with an Acute Coronary Syndrome (ACS). Aim: to explore the incidence and prognostic impact of in-hospital bleeding in patients presenting with ACS before and during the COVID-19 pandemic. Methods: We evaluated in-hospital Thrombolysis In Myocardial Infarction (TIMI) major and minor bleeding among 2851 patients with ACS from 17 Italian centers during the first wave of the COVID-19 pandemic (i.e., March-April 2020) and in the same period in the previous two years. Results: The incidence of in-hospital TIMI major and minor bleeding was similar before and during the COVID-19 pandemic. TIMI major or minor bleeding was associated with a significant threefold increase in all-cause mortality, with a similar prognostic impact before and during the COVID-19 pandemic. Conclusions: the incidence and clinical impact of in-hospital bleeding in ACS patients was similar before and during the COVID-19 pandemic. We confirmed a significant and sizable negative prognostic impact of in-hospital bleeding in ACS patients.

引用

页数：10

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