Late postnatal transmission of HIV-1 and associated factors

被引：47
|
作者：
Taha, Taha E.
Hoover, Donald R.
Kumwenda, Newton I.
Fiscus, Susan A.
Kafulafula, George
Nkhoma, Chiwawa
Chen, Shu
Piwowar, Estelle
Broadhead, Robin L.
Jackson, J. Brooks
Miotti, Paolo G.
机构：
[1] Johns Hopkins Univ, Dept Epidemiol, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA
[3] NIH, Off AIDS Res, Bethesda, MD USA
[4] Rutgers State Univ, Dept Stat, Piscataway, NJ USA
[5] Rutgers State Univ, Inst Hlth Hlth Care Policy & Aging Res, Piscataway, NJ USA
[6] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC USA
[7] Univ Malawi, Coll Med, Dept Obstet & Gynecol, Zomba, Malawi
[8] Univ Malawi, Coll Med, Dept Pediat, Zomba, Malawi
[9] Johns Hopkins Univ, Coll Med, Minist Hlth, Res Project, Blantyre, Malawi
来源：
JOURNAL OF INFECTIOUS DISEASES | 2007年 / 196卷 / 01期
关键词：
D O I：
10.1086/518511
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Background. The present study was undertaken to determine the risk and timing of late postnatal transmission ( LPT) of human immunodeficiency virus type 1 ( HIV-1). Methods. Breast-fed infants previously enrolled in 2 trials of antiretroviral prophylaxis were monitored in Malawi. Kaplan-Meier and proportional hazard models assessed cumulative incidence and association of factors with LPT. Results. Overall, 98 infants were HIV infected, and 1158 were uninfected. The cumulative risk of LPT at age 24 months was 9.68% ( 95% confidence interval, 7.80%-11.56%). The interval hazards at 1.5-6, 6-12, 12-18, and 18-24 months were 1.22%, 4.05%, 3.48%, and 1.27%, respectively. Conclusions. The risk of LPT beyond 6 months is substantial. Weaning at 6 months could prevent 185% of LPT.
引用
收藏
页码：10 / 14
页数：5
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