The elegans of spindle assembly

被引：41

作者：

Mueller-Reichert, Thomas ^{[1
]}

Greenan, Garrett ^{[2
]}

O'Toole, Eileen ^{[3
]}

Srayko, Martin ^{[4
]}

机构：

[1] Tech Univ Dresden, Med Theoret Ctr MTZ, D-01307 Dresden, Germany

[2] Max Planck Inst Mol Cell Biol & Genet MPICBG, D-01307 Dresden, Germany

[3] Univ Colorado, Boulder Lab Electron Microscopy Cells 3D, Boulder, CO 80309 USA

[4] Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E9, Canada

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2010年 / 67卷 / 13期

基金：

加拿大自然科学与工程研究理事会; 美国国家卫生研究院;

关键词：

Mitosis; Meiosis; Microtubules; Caenorhabditis elegans; Spindle; 3D; Electron tomography; MICROTUBULE-ASSOCIATED PROTEIN; TUBULIN RING COMPLEX; AURORA-A KINASE; OOCYTE MEIOTIC MATURATION; PLUS-END-TRACKING; CAENORHABDITIS-ELEGANS; C-ELEGANS; GAMMA-TUBULIN; CENTROSOME DUPLICATION; YEAST SPINDLE;

D O I：

10.1007/s00018-010-0324-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Caenorhabditis elegans one-cell embryo is a powerful system in which to study microtubule organization because this large cell assembles both meiotic and mitotic spindles within the same cytoplasm over the course of 1 h in a stereotypical manner. The fertilized oocyte assembles two consecutive acentrosomal meiotic spindles that function to reduce the replicated maternal diploid set of chromosomes to a single-copy haploid set. The resulting maternal DNA then unites with the paternal DNA to form a zygotic diploid complement, around which a centrosome-based mitotic spindle forms. The early C. elegans embryo is amenable to live-cell imaging and electron tomography, permitting a detailed structural comparison of the meiotic and mitotic modes of spindle assembly.

引用

页码：2195 / 2213

页数：19

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