The elegans of spindle assembly

被引：41
|
作者：
Mueller-Reichert, Thomas [1 ]
Greenan, Garrett [2 ]
O'Toole, Eileen [3 ]
Srayko, Martin [4 ]
机构：
[1] Tech Univ Dresden, Med Theoret Ctr MTZ, D-01307 Dresden, Germany
[2] Max Planck Inst Mol Cell Biol & Genet MPICBG, D-01307 Dresden, Germany
[3] Univ Colorado, Boulder Lab Electron Microscopy Cells 3D, Boulder, CO 80309 USA
[4] Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E9, Canada
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2010年 / 67卷 / 13期
基金：
加拿大自然科学与工程研究理事会; 美国国家卫生研究院;
关键词：
Mitosis; Meiosis; Microtubules; Caenorhabditis elegans; Spindle; 3D; Electron tomography; MICROTUBULE-ASSOCIATED PROTEIN; TUBULIN RING COMPLEX; AURORA-A KINASE; OOCYTE MEIOTIC MATURATION; PLUS-END-TRACKING; CAENORHABDITIS-ELEGANS; C-ELEGANS; GAMMA-TUBULIN; CENTROSOME DUPLICATION; YEAST SPINDLE;
D O I：
10.1007/s00018-010-0324-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Caenorhabditis elegans one-cell embryo is a powerful system in which to study microtubule organization because this large cell assembles both meiotic and mitotic spindles within the same cytoplasm over the course of 1 h in a stereotypical manner. The fertilized oocyte assembles two consecutive acentrosomal meiotic spindles that function to reduce the replicated maternal diploid set of chromosomes to a single-copy haploid set. The resulting maternal DNA then unites with the paternal DNA to form a zygotic diploid complement, around which a centrosome-based mitotic spindle forms. The early C. elegans embryo is amenable to live-cell imaging and electron tomography, permitting a detailed structural comparison of the meiotic and mitotic modes of spindle assembly.
引用
收藏
页码：2195 / 2213
页数：19
相关论文
共 50 条
  • [1] The elegans of spindle assembly
    Thomas Müller-Reichert
    Garrett Greenan
    Eileen O’Toole
    Martin Srayko
    Cellular and Molecular Life Sciences, 2010, 67 : 2195 - 2213
  • [2] Oocyte Meiotic Spindle Assembly in C. elegans
    Connolly, A. A.
    Lu, C.
    Chicas-Cruz, K.
    Lockery, S.
    Mains, P. E.
    Bowerman, B.
    MOLECULAR BIOLOGY OF THE CELL, 2013, 24
  • [3] Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans
    Risa Kitagawa
    Ann M. Rose
    Nature Cell Biology, 1999, 1 : 514 - 521
  • [4] Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans
    Kitagawa, R
    Rose, AM
    NATURE CELL BIOLOGY, 1999, 1 (08) : 514 - 521
  • [5] Spindle assembly checkpoint strength is linked to cell fate in the Caenorhabditis elegans embryo
    Gerhold, Abigail R.
    Poupart, Vincent
    Labbe, Jean-Claude
    Maddox, Paul S.
    MOLECULAR BIOLOGY OF THE CELL, 2018, 29 (12) : 1435 - 1448
  • [6] Mechanisms of acentrosomal spindle assembly during C. elegans oocyte meiosis
    Wignall, S. M.
    Villeneuve, A.
    MOLECULAR BIOLOGY OF THE CELL, 2011, 22
  • [7] Microtubule assembly and pole coalescence: early steps in Caenorhabditis elegans oocyte meiosis I spindle assembly
    Chuang, Chien-Hui
    Schlientz, Aleesa J.
    Yang, Jie
    Bowerman, Bruce
    BIOLOGY OPEN, 2020, 9 (06):
  • [8] Spindle assembly checkpoint proteins regulate and monitor meiotic synapsis in C. elegans
    Bohr, Tisha
    Nelson, Christian R.
    Klee, Erin
    Bhalla, Needhi
    JOURNAL OF CELL BIOLOGY, 2015, 211 (02): : 233 - 242
  • [9] Three-dimensional reconstructions of the first mitotic spindle reveals a novel mechanism for spindle assembly in C. elegans.
    Redemann, S.
    Kratz, A.
    Needleman, D.
    Prohaska, S.
    Mueller-Reichert, T.
    MOLECULAR BIOLOGY OF THE CELL, 2014, 25
  • [10] The spindle assembly function of Caenorhabditis elegans katanin does not require microtubule-severing activity
    McNally, Karen Perry
    McNally, Francis J.
    MOLECULAR BIOLOGY OF THE CELL, 2011, 22 (09) : 1550 - 1560
12345