Solvent free synthesis, anti-inflammatory and anticancer activity evaluation of tricyclic and tetracyclic benzimidazole derivatives

被引：69
|
作者：
Sondhi, Sham M. [1 ]
Rani, Reshma [1 ]
Singh, Jaiveer [1 ]
Roy, Partha [2 ]
Agrawal, S. K. [3 ]
Saxena, A. K. [3 ]
机构：
[1] Indian Inst Technol Roorkee, Dept Chem, Roorkee 247667, Uttar Pradesh, India
[2] Indian Inst Technol Roorkee, Dept Biotechnol, Roorkee 247667, Uttar Pradesh, India
[3] Indian Inst Integrat Med, Div Pharmacol, Jammu 180001, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 07期
关键词：
Benzimidazole; Heterocyclic; Anti-inflammatory; Anticancer; Microwave; KINASE; TRYPTANTHRIN; INHIBITORS; ALKALOIDS; PRODUCTS; ANALOGS; ASSAY;
D O I：
10.1016/j.bmcl.2010.01.147
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Heterocyclic benzimidazole derivatives 3a-h, 5a-c and 7a-d have been synthesized by condensation of succinic acid (1) homophthalic acid (4) and 2,3-pyrazinedicarboxlic acid (6) with various substituted diamines under microwave irradiation in good yields. Structures assigned to 3a-h, 5a-c and 7a-d are fully supported by spectral data. All these compounds were screened for anti-inflammatory and anticancer activities. At a dose of 50 mg/kg po compounds 3b (39.4%) and 3c (39.2%) exhibited anti-inflammatory activity, comparable to standard ibuprofen which showed 39% activity at 50 mg/kg po and compound 7c exhibit good anticancer activity against ovary (IGR-OV-1), breast (MCF-7) and CNS(SF-295) human cancer cell lines. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2306 / 2310
页数：5
相关论文
共 50 条
  • [21] Synthesis of Novel Tylophorine Derivatives and Evaluation of Their Anti-Inflammatory Activity
    Wen, Ti
    Wang, Ziwen
    Meng, Xianyi
    Wu, Meng
    Li, Yangguang
    Wu, Xiaoli
    Zhao, Liqing
    Wang, Puyue
    Yin, Zhinan
    Li-Ling, Jesse
    Wang, Qingmin
    ACS MEDICINAL CHEMISTRY LETTERS, 2014, 5 (09): : 1027 - 1031
  • [22] Synthesis and anti-inflammatory activity evaluation of novel chroman derivatives
    Matta, Akanksha
    Sharma, Ajendra K.
    Tomar, Shilpi
    Cao, Pei
    Kumar, Sandeep
    Balwani, Sakshi
    Ghosh, Balaram
    Prasad, Ashok K.
    Van der Eycken, Erik V.
    DePass, Anthony L.
    Wengel, Jesper
    Parmar, Virinder S.
    Len, Christophe
    Singh, Brajendra K.
    NEW JOURNAL OF CHEMISTRY, 2020, 44 (32) : 13716 - 13727
  • [23] Synthesis and evaluation of tricyclic dipyrido diazepinone derivatives as inhibitors of secretory phospholipase A2 with anti-inflammatory activity
    Thimmegowda, N. R.
    Dharmappa, K. K.
    kumar, C. S. Ananda
    Sadashiva, M. P.
    Sathish, A. D.
    Nanda, B. L.
    Vishwanath, B. S.
    Rangappa, K. S.
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2007, 7 (08) : 811 - 820
  • [24] Synthesis and Evaluation of Anti-Inflammatory and Antitussive Activity of Hydantion Derivatives
    Lu, Haibin
    Kong, Dejuan
    Wu, Bin
    Wang, Shihan
    Wang, Yongsheng
    LETTERS IN DRUG DESIGN & DISCOVERY, 2012, 9 (06) : 638 - 642
  • [25] Synthesis of Bis-acridine Derivatives Exhibiting Anticancer and Anti-inflammatory Activity
    Sondhi, Sham M.
    Kumar, Sandeep
    Rani, Reshma
    Chakraborty, Ajanta
    Roy, Partha
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2013, 50 (02) : 252 - 260
  • [26] Synthesis, In Vitro Anticancer, Anti-Inflammatory and DNA Binding Activity of Thiazolidinedione Derivatives
    Uwabagira, Nadine
    Sarojini, Balladka K.
    Prabhu, Ashwini
    ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2020, 20 (14) : 1704 - 1713
  • [27] Synthesis, Anti-Inflammatory, and Anticancer Activity Evaluation of Some Heterocyclic Amidine and Bis-Amidine Derivatives
    Sondhi, Sham M.
    Rani, Reshma
    Roy, Partha
    Agrawal, S. K.
    Saxena, A. K.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2011, 48 (04) : 921 - 926
  • [28] Synthesis, In Vivo and In Silico Evaluation of Analgesic, Anti-Inflammatory and Antidiarrheal Activities of Benzimidazole Derivatives
    Poddar, Saikat Kumar
    Saha, Poushali
    Spriha, Sabiha Enam
    Rahman, S. M. Abdur
    CHEMISTRYSELECT, 2025, 10 (09):
  • [29] Synthesis of Tricyclic Pterolobirin H Analogue: Evaluation of Anticancer and Anti-Inflammatory Activities and Molecular Docking Investigations
    Zentar, Houda
    Jannus, Fatin
    Medina-O'Donnell, Marta
    El Mansouri, Az-eddine
    Fernandez, Antonio
    Justicia, Jose
    Alvarez-Manzaneda, Enrique
    Reyes-Zurita, Fernando J.
    Chahboun, Rachid
    MOLECULES, 2023, 28 (17):
  • [30] Synthesis, anti-inflammatory and analgesic activities evaluation of some mono, bi and tricyclic pyrimidine derivatives
    Sondhi, SM
    Singh, N
    Johar, M
    Kumar, A
    BIOORGANIC & MEDICINAL CHEMISTRY, 2005, 13 (22) : 6158 - 6166
12345