AAV Mediated Expression of Mouse IL-12 Shows Potent Anti-Tumor Activity and Immune Response Alone and in Combination with Anti-PD1 in Syngeneic Murine Tumor Models

被引：0
|
作者：
Sutton, David [1 ]
Prentiss, Pilar [1 ]
Furmanski, Brian [1 ]
机构：
[1] Kriya Therapeut, Translat Dev, Redwood City, CA USA
来源：
MOLECULAR THERAPY | 2022年 / 30卷 / 04期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
337
引用
收藏
页码：161 / 161
页数：1
相关论文
共 50 条
  • [21] The combination therapy of oncolytic HSV-1 armed with anti-PD-1 antibody and IL-12 enhances anti-tumor efficacy
    Xie, Xin
    Lv, Jingwen
    Zhu, Wei
    Tian, Chao
    Li, Jingfeng
    Liu, Jiajia
    Zhou, Hua
    Sun, Chunyang
    Hu, Zongfeng
    Li, Xiaopeng
    TRANSLATIONAL ONCOLOGY, 2022, 15 (01):
  • [22] Anti-tumor activity of mesenchymal stem cells producing IL-12 in a mouse melanoma model
    Elzaouk, Lina
    Moelling, Karin
    Pavlovic, Jovan
    EXPERIMENTAL DERMATOLOGY, 2006, 15 (11) : 865 - 874
  • [23] Gene therapy with IL-12 induced enhanced anti-tumor activity in fibrosarcoma mouse model
    Soofiyani, Saiedeh Razi
    Kazemi, Tohid
    Lotfipour, Farzaneh
    Hosseini, Akbar Mohammad
    Shanehbandi, Dariush
    Hallaj-Nezhadi, Somayeh
    Baradaran, Behzad
    ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2016, 44 (08) : 1988 - 1993
  • [24] Combination of the angiogenesis inhibitor lucitanib with immune checkpoint blockade augments anti-tumor activity in syngeneic models
    Dusek, Rachel
    Robillard, Liliane
    Harding, Thomas
    Simmons, Andrew
    Minh Nguyen
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
  • [25] WTX-330, a conditionally activated IL-12 INDUKINE, releases IL-12 selectively in the tumor microenvironment to activate anti-tumor immune responses and induce regressions in mouse tumor models.
    Steiner, Philipp
    Brodkin, Heather
    Hicklin, Dan
    Ismail, Nesreen
    Morris, Kristin
    Nirschl, Christopher
    Salmeron, Andres
    Seidel-Dugan, Cindy
    Steuert, Zoe
    Sullivan, Jenna
    Winston, William
    CANCER RESEARCH, 2021, 81 (13)
  • [26] ANCHORED IMMUNOTHERAPY WITH INTRATUMORALLY ADMINISTERED ALUMINUM HYDROXIDE-TETHERED IL-12 INDUCES POTENT ANTI-TUMOR IMMUNE RESPONSE
    Battula, Sailaja
    Papastoitsis, Gregory
    Kaufman, Howard
    Wittrup, K.
    Schmidt, Michael
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A1118 - A1118
  • [27] INTRATUMORAL ADMINISTRATION AND LOCAL RETENTION OF IL-2/IL-12 FUSION PROTEINS DRIVE A POTENT SYSTEMIC ANTI-TUMOR IMMUNE RESPONSE
    Naveen, Mehta
    Li, Bochong
    Wittrup, Dane
    Baeuerle, Patrick
    Michaelson, Jennifer
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 : A918 - A918
  • [28] Methotrexate preserves anti-PD1 anti-tumor benefits while reducing arthritic inflammation in a tumor and ICI-arthritis combination mouse model
    Papadopoulos, Theodore
    Santinon, Francois
    Naranjo, Carolina Lopez
    Hudson, Marie
    Del Rincon, Sonia Victoria
    CANCER IMMUNOLOGY RESEARCH, 2025, 13 (02)
  • [29] A PD-1 peptide antagonist exhibits potent anti-tumor and immune regulatory activity
    Tao, Huimin
    Cheng, Lu
    Liu, Lihua
    Wang, Hong
    Jiang, Zhijie
    Qiang, Xu
    Xing, Lijun
    Xu, Yifeng
    Cai, Xinying
    Yao, Jing
    Wang, Min
    Qiu, Zheng
    CANCER LETTERS, 2020, 493 : 91 - 101
  • [30] IFN-γ-independent synergistic effects of IL-12 and IL-15 induce anti-tumor immune responses in syngeneic mice
    Comes, A
    Di Carlo, E
    Musiani, P
    Rosso, O
    Meazza, R
    Chiodoni, C
    Colombo, MP
    Ferrini, S
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2002, 32 (07) : 1914 - 1923
12345