Crystal structure of 2,8-dimethyl-3-chloro-4H-pyrido[1,2-a]pyrimidin-4-one

被引：1
|
作者：
Anthal, S. [1 ]
Dutt, P. [2 ]
Satti, N. K. [2 ]
Kant, R. [1 ]
Gupta, V. K. [1 ]
机构：
[1] Univ Jammu, Postgrad Dept Phys & Elect, Jammu 180006, India
[2] Indian Inst Integrat Med, Nat Prod Chem Div, Jammu 180001, India
来源：
CRYSTALLOGRAPHY REPORTS | 2014年 / 59卷 / 07期
关键词：
RECEPTOR ANTAGONISTS; DERIVATIVES; INHIBITORS; SOLUBILITY;
D O I：
10.1134/S1063774514070025
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
The title compound, 2,8-dimethyl-3-chloro-4H-pyrido[1,2-a]pyrimidin-4-one, (C10H9ClN2O), was synthesized, and its structure was established by spectral analysis and X-ray diffraction studies. There are two independent molecules per asymmetric unit. In both the molecules, the pyrido-pyrimidine moiety is planar with a dihedral angle of 3.53(9)A degrees for molecule A and 1.61(9)A degrees for molecule B. The crystal structure is stabilized by C-Ha <-O and C-Ha <-Cl hydrogen bonds. The pi-pi interactions were also observed between the A and B molecules. The pyrido-pyrimidine moiety is not involved in any C-Ha <-pi contacts.
引用
收藏
页码：1005 / 1009
页数：5
相关论文
共 50 条
  • [21] Synthesis, characterization and cytotoxic activity of diorganotin(IV) complexes with 4H-pyrido[1,2-a]pyrimidin-4-one derivatives
    AlAllaf, TAK
    AlBayati, RIH
    Rashan, LJ
    Khuzaie, RF
    APPLIED ORGANOMETALLIC CHEMISTRY, 1996, 10 (01) : 47 - 51
  • [22] POTENTIAL AMBIFUNCTIONALITY OF 2-AZIDOPYRIDO [1,2-A] PYRIMIDIN-4-ONE
    KOVACIC, M
    POLANC, S
    STANOVNIK, B
    TISLER, M
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1974, 11 (06) : 949 - 952
  • [23] 3-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-2-methyl -4H-pyrido[1,2-a]pyrimidin-4-one (pirenperone)
    Blaton, N.M.
    Peeters, O.M.
    De Ranter, C.J.
    Acta Crystallographica, Section C: Crystal Structure Communications, 1995, 51 (pt 3):
  • [24] 3-BENZOYL-2-HYDROXY-9-METHYLPYRIDO[1,2-A]PYRIMIDIN-4-ONE
    YALE, HL
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1978, 15 (06) : 1047 - 1049
  • [25] p-Toluenesulfonic Acid Catalyzed One-Pot Synthesis of 4H-Pyrido[1,2-a]pyrimidin-4-one Derivatives
    Liu, Wenjie
    Wang, Shaohua
    Zhan, Haiying
    Li, Mingshan
    SYNLETT, 2014, 25 (10) : 1478 - 1481
  • [26] STRUCTURE OF THE ANTIPSYCHOTIC DRUG 3-(2-[4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)-1-PIPERIDINYL]ETHYL)-2,9-DIMETHYL-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE (OCAPERIDONE)
    JOTTIER, WI
    DEWINTER, HL
    PEETERS, OM
    BLATON, NM
    DERANTER, CJ
    ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1992, 48 : 1827 - 1830
  • [27] 2-Trifluoromethyl-10H-benzo[4,5]imidazo[1,2-a] pyrimidin-4-one
    Chandra
    Puttaraju, K. B.
    Shivashankar, K.
    Babu, E. A. Jithesh
    Mahendra, M.
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2013, 69 : O1536 - +
  • [28] A FACILE AND PRACTICAL SYNTHESIS OF 9-METHYL-3-(1H-TETRAZOL-5-YL)-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE
    SANO, A
    ISHIHARA, M
    YOSHIHARA, J
    SUMINO, M
    NAWA, H
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1995, 43 (04) : 683 - 685
  • [29] Synthesis, anticancer activity and molecular docking studies of novel pyrido[1,2-a]pyrimidin-4-one derivatives
    Luo, Zhibin
    Valeru, Anil
    Penjarla, Srishylam
    Liu, Bin
    Khan, Imran
    SYNTHETIC COMMUNICATIONS, 2019, 49 (17) : 2235 - 2243
  • [30] Substituted Pyridopyrimidinones. Part 3. Synthesis of Some Novel Ether Derivatives of 4H-Pyrido[1,2-a]pyrimidin-4-one
    Abass, Mohamed
    Ismail, Mostafa M.
    Abdel-Monem, Wafaa R.
    Mayas, Aisha S.
    JOURNAL OF THE MEXICAN CHEMICAL SOCIETY, 2009, 53 (02) : 48 - 54
12345