An integrated strategy for the discovery of drug targets by the analysis of protein-protein interactions

被引：3

作者：

Peltier, JM ^{[1
]}

Askovic, S ^{[1
]}

Becklin, RR ^{[1
]}

Chepanoske, CL ^{[1
]}

Ho, YSJ ^{[1
]}

Kery, V ^{[1
]}

Lai, SP ^{[1
]}

Mujtaba, T ^{[1
]}

Pyne, M ^{[1
]}

Robbins, PB ^{[1
]}

von Rechenberg, M ^{[1
]}

Richardson, B ^{[1
]}

Savage, J ^{[1
]}

Sheffield, P ^{[1
]}

Thompson, S ^{[1
]}

Weir, L ^{[1
]}

Widjaja, K ^{[1
]}

Xu, NF ^{[1
]}

Zhen, YJ ^{[1
]}

Boniface, JJ ^{[1
]}

机构：

[1] Prolexys Pharmaceut Inc, Salt Lake City, UT 84116 USA

来源：

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY | 2004年 / 238卷 / 02期

关键词：

protein interactions; MS/MS; affinity tags; drug discovery; drug targets;

D O I：

10.1016/j.ijms.2003.12.039

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

Proteomics-based technologies have the potential to accelerate the development of drugs, but such technologies must be well integrated in order to have a positive impact. We describe, herein, a multi-step process for the discovery of protein-protein interactions. It is shown that process stages are interdependent and can influence, either positively or negatively, subsequent steps. Optimization of each step, in the context of the full process, is essential for the overall success of the experiment. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：119 / 130

页数：12

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