Protective effect of a gonadotropin-releasing hormone analogue on chemotherapeutic agent-induced ovarian gonadotoxicity: A mouse model

被引:20
|
作者
Tan, Shun-Jen [1 ]
Yeh, Yu-Chi [2 ]
Shang, Wei-Jen [1 ]
Wu, Gwo-Jang [1 ]
Liu, Jah-Yao [1 ]
Chen, Chi-Huang [1 ]
机构
[1] Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Obstet & Gynecol, Taipei 114, Taiwan
[2] Cathay Gen Hosp, Dept Psychiat, Taipei, Taiwan
关键词
GnRH analogue; Fertility preservation; Ovarian protection; Primordial follicles; Gonadotoxicity; FERTILITY PRESERVATION; FEMALE-PATIENTS; BREAST-CANCER; CHILDHOOD-CANCER; YOUNG-WOMEN; STEM-CELLS; AGONIST; RESERVE; CYCLOPHOSPHAMIDE; MICE;
D O I
10.1016/j.ejogrb.2009.12.028
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To demonstrate the protective effect of triptorelin, a GnRH analogue, on chemotherapy-induced ovarian gonadotoxicity. Study design: Twenty-four sexually mature, virgin, female FVB/NJNarl mice were divided into four groups: busulfan (B); low-dose triptorelin plus busulfan (T-L + B); high-dose triptorelin plus busulfan (T-H + B); and control. Mice in the T-L + B and T-H + B groups were injected with 3.8 and 38 mg/kg of triptorelin subcutaneously, respectively. Four weeks later, mice in the B, T-L + B. and T-H + B groups were injected with busulfan intraperitoneally at a dose of 36 mg/kg. Histologic examinations were performed 4 weeks later. Results: Obvious destruction of ovarian structure and significant depletion of primordial, primary, and secondary follicles were demonstrated in the B group compared with the control group, affirming the gonadotoxicity of busulfan. In the T-L + B group, a greater number of larger primordial and primary follicles were enumerated compared with the B group; however, statistical significance was not achieved. In the T-H + B group, the number of primordial and primary follicles was significantly greater than in the B group, and the ovarian tissue in the T-H + B group was spared, demonstrating the effect of triptorelin pre-treatment on ovarian protection. Conclusion: Our results have demonstrated a dose-dependent protective effect against gonadotoxic chemotherapy of a GnRH analogue on ovarian reserve, thus suggesting a novel application of GnRH analogues in fertility preservation. Crown Copyright (C) 2009 Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:182 / 185
页数:4
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