A new 2-(4H-1,3-benzoxazin-4-on-2-yl)-1,3-tropolone: Synthesis, structure, and antibacterial properties

被引：12
|
作者：
Sayapin, Yu A. [1 ]
Gusakov, E. A. [2 ]
Dorogan, I. V. [2 ]
Tupaeva, I. O. [2 ]
Teimurazov, M. G. [3 ]
Fursova, N. K. [3 ]
Ovchinnikov, K. V. [3 ]
Minkin, V. I. [1 ,2 ]
机构：
[1] Russian Acad Sci, Southern Sci Ctr, Ul Chekhova 41, Rostov Na Donu 344006, Russia
[2] Southern State Univ, Res Inst Phys & Organ Chem, Rostov Na Donu 344090, Russia
[3] State Sci Ctr Appl Microbiol & Biotechnol, Obolensk 142279, Moscow Oblast, Russia
来源：
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2016年 / 42卷 / 02期
基金：
俄罗斯基础研究基金会;
关键词：
2-methyl-4H-3,1-benzoxazin-4-one; 1,3-tropolone; antibacterial activity; Escherichia coli; Acinetobacter baumannii; Staphylococcus aureus; Salmonella enterica sv. Enteritidis; and Pseudomonas aeruginosa;
D O I：
10.1134/S1068162016020114
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
2-(4H-1,3-Benzoxazin-4-on-2-yl)-4,5,6-trichloro-1,3-tropolone, structural properties of which were studied using H-1 NMR, IR-spectroscopy, mass spectrometry, and quantum chemistry has been obtained for the first time using an acid-catalyzed condensation reaction of 3,4,5,6-tetrachloro-1,2-benzoquinone with 2-methyl-4H-3,1-benzoxazin-4-one. It has been shown that the new tropolone possesses antibacterial activity against hospital-acquired strains of gram-negative (Escherichia coli, Salmonella enterica sv. Enteritidis, Acinetobacter baumannii, and Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacteria. The obtained substance is suggested for development of a new antibacterial drug.
引用
收藏
页码：224 / 228
页数：5
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