Risk Factors and Frequency of Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome among HIV/Tuberculosis Co-infected Patients in Southern India

被引:10
|
作者
Vignesh, Ramachandran [1 ,2 ]
Swathirajan, Chinnambedu R. [1 ]
Solomon, Sunil S. [3 ,4 ]
Shankar, Esaki Muthu [1 ]
Murugavel, Kailapuri G. [1 ]
机构
[1] YR Gaitonde Ctr AIDS Res & Educ, Infect Dis Lab, 2 Floor,Admin Bldg,VHS Hosp Campus, Madras 600113, Tamil Nadu, India
[2] YR Gaitonde Ctr AIDS Res & Educ, Med Ctr, Madras, Tamil Nadu, India
[3] Univ Kuala Lumpur, Royal Coll Med Perak, Lab Based Dept, Ipoh, Malaysia
[4] Johns Hopkins Sch Med, Dept Infect Dis, Baltimore, MD USA
关键词
HIV; HIV/tuberculosis; immune reconstitution inflammatory syndrome; opportunistic infection; tuberculosis-immune reconstitution inflammatory syndrome; tuberculosis; GENERIC ANTIRETROVIRAL THERAPY; HIV; INITIATION; DISEASE; IRIS; TB;
D O I
10.4103/ijmm.IJMM_16_163
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Immune reconstitution inflammatory syndrome (IRIS) continues to be a complication in HIV/tuberculosis (TB) co-infected patients initiating highly active antiretroviral therapy (HAART). The aim of this study was to evaluate the risk factors associated with developing IRIS to identify a possible biomarker to predict or diagnose IRIS in patients initiating HAART. A total of 175 HIV/TB co-infected patients initiating HAART were followed up longitudinally during September 2010 to May 2013 attending a HIV care clinic in Chennai. Patients were followed up longitudinally after HAART initiation and baseline demographic, laboratory parameters and treatment characteristics between patients with IRIS events and those without IRIS events were compared. Chi-square or Fisher's exact test for categorical variables and a Wilcoxon rank-sum test for continuous variables were performed using SPSS, version 12.0 software. Patients with IRIS had a significantly lower median baseline CD4+ T-cell count (P = 0.0039). There were no differences in terms of sex, CD4 T-cell %, plasma viral load, time interval between initiating ATT and HAART between the IRIS and non-IRIS patients. Low CD4+ T-cell count (< 100 cells/mu L) could be used as a marker to screen and monitor patients initiating HAART.
引用
收藏
页码:279 / 281
页数:3
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