Chiral bidentate lithium amides having a chiral amide nitrogen for enantioselective deprotonation of 4-tert-butylcycloxexanone

被引：0

作者：

Chatani, H ^{[1
]}

Nakajima, M ^{[1
]}

Kawasaki, K ^{[1
]}

Koga, K ^{[1
]}

机构：

[1] Univ Tokyo, Fac Pharmaceut Sci, Bunkyo Ku, Tokyo 113, Japan

来源：

HETEROCYCLES | 1997年 / 46卷

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective deprotonation of 4-tert-butylcyclohexanone (1) by chiral bidentate lithium amides ((R)-5a similar to b) was examined in the presence of excess TMSCl in several solvents containing 2 equivalents of HMPA. The sense of asymmetric induction was found to be the same with that by using (R)-2a similar to b. This result suggests the formation of a similar chiral amide nitrogen in these chiral lithium amides.

引用

页码：53 / 56

页数：4

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