Efficient inhibition of Notch3 and Notch4 family members in vivo by a dominant negative mutant of mastermind.

被引：0
|
作者：
Pross, S
Millholland, JM
Sai, H
Weng, AP
Aster, JC
Pear, WS
Maillard, I
机构：
[1] Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
[3] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA
[4] Univ Penn, Div Hematol Oncol, Philadelphia, PA 19104 USA
来源：
BLOOD | 2004年 / 104卷 / 11期
关键词：
D O I：
10.1182/blood.V104.11.1617.1617
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
1617
引用
收藏
页码：449A / 450A
页数：2
相关论文
共 34 条
  • [21] Inhibition of NOTCH4 Sensitizes FLT3/ITD Acute Myeloid Leukemia Cells to FLT3 Tyrosine Kinase Inhibition
    Zhu, Ruiqi
    Shirley, Courtney
    Chu, Haihua
    Li, Li
    Bao Nguyen
    Seo, Jaesung
    Seale, Tessa
    Duffield, Amy
    Staudt, Louis M.
    Levis, Mark J.
    Hu, Yu
    Small, Donald
    BLOOD, 2023, 142
  • [22] CADASIL and Autoimmunity: Coexistence in a Family with the R169C Mutation at Exon 4 of the NOTCH3 Gene
    Paraskevas, George P.
    Bougea, Anastasia
    Synetou, Margarita
    Vassilopoulou, Sophia
    Anagnostou, Evangelos
    Voumvourakis, Konstantinos
    Iliopoulos, Alexios
    Spengos, Konstantinos
    CEREBROVASCULAR DISEASES, 2014, 38 (04) : 302 - 307
  • [23] Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers
    Haruki, N
    Kawaguchi, KS
    Eichenberger, S
    Massion, PP
    Olson, S
    Gonzalez, A
    Carbone, DP
    Dang, TP
    CANCER RESEARCH, 2005, 65 (09) : 3555 - 3561
  • [24] Evaluation of NOTCH3 Pro167Ser Variation in a Japanese Family with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
    Mizuno, Toshiki
    Mizuta, Ikuko
    Tomimoto, Hidekazu
    DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA, 2016, 6 (02): : 183 - +
  • [25] Potent inhibitors of amyloid β fibrillization, 4,5-dianilinophthalimide and staurosporine aglycone, enhance degradation of preformed aggregates of mutant Notch3
    Takahashi, Keikichi
    Adachi, Kayo
    Kunimoto, Shohko
    Wakita, Hideaki
    Takeda, Kazuya
    Watanabe, Atsushi
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 402 (01) : 54 - 58
  • [26] A novel mutation in the Notch3 gene in an Italian family with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy -: Genetic and magnetic resonance spectroscopic findings
    Oliveri, RL
    Muglia, M
    De Stefano, N
    Mazzei, R
    Labate, A
    Conforti, FL
    Patitucci, A
    Gabriele, AL
    Tagarelli, G
    Magariello, A
    Zappia, M
    Gambardella, A
    Federico, A
    Quattrone, A
    ARCHIVES OF NEUROLOGY, 2001, 58 (09) : 1418 - 1422
  • [27] Arg332Cys mutation of NOTCH3 gene in the first known Taiwanese family with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    Tang, SC
    Lee, MJ
    Jeng, JS
    Yip, PK
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2005, 228 (02) : 125 - 128
  • [28] Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Family Members With a Pathogenic NOTCH3 Variant Can Have a Normal Brain Magnetic Resonance Imaging and Skin Biopsy Beyond Age 50 Years
    Hack, Remco J.
    Gravesteijn, Gido
    Cerfontaine, Minne N.
    Hegeman, Ingrid M.
    Mulder, Aat A.
    Oberstein, Saskia A. J. Lesnik
    Rutten, Julie W.
    STROKE, 2022, 53 (06) : 1964 - 1974
  • [29] Genetic and Pharmacologic Notch4 Inhibition Synergizes with FLT3 Tyrosine Kinase Inhibition in Vitro to More Effectively Eliminate FLT3/ITD-Positive Leukemia Cells
    Shirley, Courtney M.
    Chu, S. Haihua
    Yang, Yandan
    Wright, George W.
    Staudt, Louis M.
    Small, Donald
    BLOOD, 2014, 124 (21)
  • [30] Inhibition of HBV replication by VPS4B and its dominant negative mutant VPS4B-K180Q in vivo
    Jianbo Xia
    Weipeng Wang
    Lei Li
    Zhi Liu
    Min Liu
    Dongliang Yang
    Journal of Huazhong University of Science and Technology [Medical Sciences], 2012, 32 : 311 - 316
1234