Rhodium(III)-catalyzed C-H activation and intermolecular annulation with terminal alkynes: from indoles to carbazoles

被引：77

作者：

Jia, Jinlong ^{[1
,2
]}

Shi, Jingjing ^{[1
]}

Zhou, Jie ^{[1
,3
]}

Liu, Xuelei ^{[1
]}

Song, Yanling ^{[2
]}

Xu, H. Eric ^{[1
,4
]}

Yi, Wei ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, VARI SIMM Ctr,Ctr Struct & Funct Drug Targets, Shanghai 201203, Peoples R China

[2] Shenyang Univ Chem Technol, Coll Pharmaceut & Biol Engn, Shenyang 110142, Peoples R China

[3] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

[4] Van Andel Res Inst, Program Struct Biol & Drug Discovery, Lab Struct Sci, Grand Rapids, MI 49503 USA

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 14期

关键词：

N BOND FORMATION; EFFICIENT SYNTHESIS; ALKYNYLATION; FUNCTIONALIZATION; ARENES; RH; ALKENYLATION; ALKALOIDS; HYDROGENATION; HETEROCYCLES;

D O I：

10.1039/c4cc09823d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein we disclose the first example of Rh(III)-catalyzed intermolecular annulation of indoles with terminal alkynes to give highly efficient one-pot access to privileged carbazoles. The mild reaction features moderate to good yields, exclusive regioselectivity, broad substrate scope, and excellent functional group tolerance.

引用

页码：2925 / 2928

页数：4

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