A New Benzophenone C-Glucoside and Other Constituents of Pseuduvaria fragrans and Their α-Glucosidase Inhibitory Activity

被引：17

作者：

Panidthananon, Wongvarit ^{[1
]}

Chaowasku, Tanawat ^{[2
,3
]}

Sritularak, Boonchoo ^{[1
]}

Likhitwitayawuid, Kittisak ^{[1
]}

机构：

[1] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Pharmacognosy & Pharmaceut Bot, Bangkok 10330, Thailand

[2] Chiang Mai Univ, Fac Sci, Dept Biol, 239 Huay Kaew Rd, Chiang Mai 50200, Thailand

[3] Chiang Mai Univ, Ctr Excellence Bioresources Agr Ind & Med, Chiang Mai 50200, Thailand

来源：

MOLECULES | 2018年 / 23卷 / 07期

关键词：

benzophenone; glycoside; aporphine; azafluorenone; tyramine amide; alpha-glucosidase; uncompetitive inhibition; ALKALOIDS; AMIDES; INDOCHINENSIS; LEAVES; RUGOSA; STEMS; ACID;

D O I：

10.3390/molecules23071600

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phytochemical investigations of the leaves and stems of Pseuduvaria fragrans led to the isolation of a new benzophenone C-glucoside named pseuduvarioside (1), together with six known compounds including (-)-guaiol (2), (+)-isocorydine (3), cyathocaline (4), isoursoline (5), N-trans-coumaroyltyramine (6), and N-trans-feruloyltyramine (7). Their structures were characterized by NMR spectroscopy and mass spectrometry. All of the isolates were evaluated for inhibitory activity against the enzyme alpha-glucosidase. N-trans-coumaroyltyramine and N-trans-feruloyltyramine showed higher activity than the drug acarbose. Kinetic studies revealed that both tyramine-derived amides were uncompetitive inhibitors of the enzyme.

引用

页数：8

共 50 条

[31] The Chemical Constituents of Diaphragma Juglandis Fructus and Their Inhibitory Effect on α-Glucosidase Activity
Tan, Jinyan
Cheng, Yangang
Wang, Shihui
Li, Jianli
Ren, Haiqin
Qiao, Yuanbiao
Li, Qingshan
Wang, Yingli
MOLECULES, 2022, 27 (10):
[32] A NEW XANTHONE C-GLUCOSIDE POSITION ISOMER OF MANGIFERIN FROM ANEMARRHENA ASPHODELOIDES BUNGE
ARITOMI, M
KAWASAKI, T
TETRAHEDRON LETTERS, 1969, (12) : 941 - &
[33] NEW XANTHONE C-GLUCOSIDE, POSITION ISOMER OF MANGIFERIN, FROM ANEMARRHENA-ASPHODELOIDES BUNGE
ARITOMI, M
KAWASAKI, T
CHEMICAL & PHARMACEUTICAL BULLETIN, 1970, 18 (11) : 2327 - +
[34] Chemical constituents from Urtica fissa stem and their inhibitory effects on α-glucosidase activity
Zhang, Ying
Liu, Jinzhao
Guo, Zixian
Li, Xiaobo
Wang, Mengyue
NATURAL PRODUCT RESEARCH, 2021, 35 (18) : 3011 - 3017
[35] Aromatic Constituents from the Leaves of Actinidia arguta with Antioxidant and α-Glucosidase Inhibitory Activity
Ahn, Jong Hoon
Ryu, Se Hwan
Lee, Solip
Yeon, Sang Won
Turk, Ayman
Han, Yoo Kyong
Lee, Ki Yong
Hwang, Bang Yeon
Lee, Mi Kyeong
ANTIOXIDANTS, 2021, 10 (12)
[36] Phenolic glycoside constituents from Brassica rapa flowers and their ?-glucosidase inhibitory activity
Zhao, Chun-Chao
Shen, Jie
Chen, Jia
Shao, Jian-Hua
Li, Ke-Huan
Gu, Wen-Yan
Miao, Ben-Jie
NATURAL PRODUCT RESEARCH, 2019, 33 (23) : 3398 - 3403
[37] Coumarins and Polar Constituents from Eupatorium triplinerve and Evaluation of Their α-Glucosidase Inhibitory Activity
Do Thi Viet Huong
Phan Minh Giang
Vu Minh Trang
JOURNAL OF CHEMISTRY, 2020, 2020
[38] Undescribed Lignanamide and Flavone C-Glucoside Isolated from the Aerial Parts of Piper Samentosum with NO Production Inhibitory Activity in LPS Activated RAW 264.7 Cells
Huyen, Le Thi
Thao, Luu Thu
Nga, Nhu Thi Hang
Ly, Quach Thi Khanh
Son, Nguyen Thi
Tai, Bui Huu
Thinh, Ngo Sy
Kiem, Phan Van
CHEMISTRY & BIODIVERSITY, 2024, 21 (05)
[39] Inhibitory Potential of Constituents from Osmanthus fragrans and Structural Analogues Against Advanced Glycation End Products, α-Amylase, α-Glucosidase, and Oxidative Stress
Ji-Yeon Yang
Jun-Hwan Park
Namhyun Chung
Hoi-Seon Lee
Scientific Reports, 7
[40] Activity and mechanism of α-glucosidase inhibitory peptides released from Osmanthus fragrans seeds protein during the in vitro digestion
Du, Jun-Hui
Yang, Dong-Mei
Guan, Tong-Tong
Wang, Jie
Ma, Yi-Long
Wei, Zhao-Jun
INDUSTRIAL CROPS AND PRODUCTS, 2024, 219

← 1 2 3 4 5 →