Discovery of prostate cancer biomarkers by microarray gene expression profiling

被引：11

作者：

Sorensen, Karina Dalsgaard ^{[1
]}

Orntoft, Torben Falck ^{[1
]}

机构：

[1] Aarhus Univ Hosp, Dept Mol Med, DK-8200 Aarhus N, Denmark

来源：

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2010年 / 10卷 / 01期

关键词：

biomarker; gene expression; gene signature; microarray; microRNA; molecular profiling; prostate cancer; METHYLACYL-COA RACEMASE; TMPRSS2-ERG FUSION TRANSCRIPTS; NEGATIVE BREAST-CANCER; MICRORNA EXPRESSION; RADICAL PROSTATECTOMY; BIOCHEMICAL RECURRENCE; PROGNOSTIC SIGNATURE; SYSTEMIC PROGRESSION; PATHWAY ACTIVATION; MOLECULAR-FEATURES;

D O I：

10.1586/ERM.09.74

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Prostate cancer is the most commonly diagnosed malignancy in males in the Western world. This review focuses on advances in biomarker discovery for prostate cancer by microarray profiling of mRNA and microRNA expression. Novel biomarkers are strongly needed to enable more accurate detection of prostate cancer, improve prediction of tumor aggressiveness and facilitate discovery of new therapeutic targets for tailored medicine. Promising molecular markers identified from gene expression profiling studies include AMACR, EZH2, TMPRSS2-ERG, miR-221 and miR-141, which are described in more detail. In addition, a compilation of prognostic gene expression signatures for prediction of prostate cancer patient outcome is provided, and their possible clinical utility is discussed. Furthermore, limitations in the application of microarray-based expression profiling for identification of prostate cancer biomarkers are addressed.

引用

页码：49 / 64

页数：16

共 50 条

[21] Analysis of microarray experiments of gene expression profiling
Tarca, Adi L.
Romero, Roberto
Draghici, Sorin
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2006, 195 (02) : 373 - 388
[22] Microarray gene expression profiling in meningiomas and schwannomas
Martinez-Glez, V.
Franco-Hernandez, C.
Rey, J. A.
CURRENT MEDICINAL CHEMISTRY, 2008, 15 (08) : 826 - 833
[23] Effects of garlic-derived compound diallyl disulfide on prostate cancer cell LNCaP gene expression: cDNA microarray expression profiling
Wang, T
Milner, M
Kim, Y
Milner, J
FASEB JOURNAL, 2003, 17 (04): : A376 - A376
[24] Gene expression profiling by DNA microarray technology
Iida, K
Nishimura, I
CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE, 2002, 13 (01) : 35 - 50
[25] Technological platforms for microarray gene expression profiling
Mandruzzato, Susanna
MICROARRAY TECHNOLOGY AND CANCER GNE PROFILING, 2007, 593 : 12 - 18
[26] Gene expression profiling predicts clinical outcome of prostate cancer
Glinsky, GV
Glinskii, AB
Stephenson, AJ
Hoffman, RM
Gerald, WL
JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (06): : 913 - 923
[27] Gene expression profiling of gastric cancer by microarray combined with laser capture microdissection
Chia-Tung Shun
Ming-Tsan Lin
Jaw-Town Lin
World Journal of Gastroenterology, 2005, (47) : 7405 - 7412
[28] Gene expression profiling of gastric cancer by microarray combined with laser capture microdissection
Wu, Ming-Shiang
Lin, Yi-Shing
Chang, Yu-Ting
Shun, Chia-Tung
Lin, Ming-Tsan
Lin, Jaw-Town
WORLD JOURNAL OF GASTROENTEROLOGY, 2005, 11 (47) : 7405 - 7412
[29] Variation in Apoptotic Gene Expression in Cervical Cancer Through Oligonucleotide Microarray Profiling
Zhu, Ming-Yue
Chen, Fan
Niyazi, Mayinuer
Sui, Shuang
Gao, Dong-Mei
JOURNAL OF LOWER GENITAL TRACT DISEASE, 2015, 19 (01) : 46 - 54
[30] The role of gene expression profiling by microarray analysis for prognostic classification of breast cancer
van de Vijver, MJ
BREAST CANCER RESEARCH, 2005, 7 (Suppl 1) : S1 - S1

← 1 2 3 4 5 →