Squaramide-catalyzed enantioselective Friedel-Crafts reaction of indoles with imines

被引：163
|
作者：
Qian, Yong [1 ]
Ma, Gaoyuan [1 ]
Lv, Aifeng [1 ]
Zhu, Hai-Liang [1 ]
Zhao, Jing [1 ,2 ]
Rawal, Viresh H. [3 ]
机构：
[1] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Sch Life Sci, Nanjing 210008, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet Chem Nat Subst, Shanghai 200032, Peoples R China
[3] Univ Chicago, Dept Chem, Chicago, IL 60637 USA
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 17期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
CHIRAL PHOSPHORIC-ACID; ASYMMETRIC CATALYSIS; BRONSTED ACID; ALKYLATION; DERIVATIVES; NITROALKENES; DONORS;
D O I：
10.1039/b922120d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Chiral squaramides are highly enantioselective catalysts for Friedel-Crafts reaction of indoles with N-tosyl imines, affording 3-indolyl methanamine products in 85-96% yields and 84-96% ees.
引用
收藏
页码：3004 / 3006
页数：3
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