Incompatible and sterile insect techniques combined eliminate mosquitoes

被引：458

作者：

Zheng, Xiaoying ^{[1
]}

Zhang, Dongjing ^{[1
,2
]}

Li, Yongjun ^{[1
,3
]}

Yang, Cui ^{[1
,3
]}

Wu, Yu ^{[1
]}

Liang, Xiao ^{[4
]}

Liang, Yongkang ^{[1
,3
]}

Pan, Xiaoling ^{[4
,5
]}

Hu, Linchao ^{[1
]}

Sun, Qiang ^{[1
,4
]}

Wang, Xiaohua ^{[3
]}

Wei, Yingyang ^{[3
]}

Zhu, Jian ^{[3
]}

Qian, Wei ^{[3
]}

Yan, Ziqiang ^{[6
]}

Parker, Andrew G. ^{[2
]}

Gilles, Jeremie R. L. ^{[2
]}

Bourtzis, Kostas ^{[2
]}

Bouyer, Jeremy ^{[2
]}

Tang, Moxun ^{[7
]}

Zheng, Bo ^{[8
]}

Yu, Jianshe ^{[8
]}

Liu, Julian ^{[3
]}

Zhuang, Jiajia ^{[1
]}

Hu, Zhigang ^{[6
]}

Zhang, Meichun ^{[1
]}

Gong, Jun-Tao ^{[9
]}

Hong, Xiao-Yue ^{[9
]}

Zhang, Zhoubing ^{[6
]}

Lin, Lifeng ^{[10
]}

Liu, Qiyong ^{[11
]}

Hu, Zhiyong ^{[12
]}

Wu, Zhongdao ^{[1
]}

Baton, Luke Anthony ^{[4
]}

Hoffmann, Ary A. ^{[13
]}

Xi, Zhiyong ^{[1
,3
,4
]}

机构：

[1] Sun Yat Sen Univ, Sun Yat Sen Univ Michigan State Univ Joint Ctr Ve, Zhongshan Sch Med, Key Lab Trop Dis Control,Minist Educ, Guangzhou, Guangdong, Peoples R China

[2] Vienna Int Ctr, Insect Pest Control Lab, Joint FAO IAEA Programme Nucl Tech Food & Agr, Vienna, Austria

[3] Guangzhou Wolbaki Biotech Co Ltd, Guangzhou, Guangdong, Peoples R China

[4] Michigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA

[5] Hunan Normal Univ, Sch Med, Changsha, Hunan, Peoples R China

[6] Guangzhou Ctr Dis Control & Prevent, Guangzhou, Guangdong, Peoples R China

[7] Michigan State Univ, Dept Math, E Lansing, MI 48824 USA

[8] Guangzhou Univ, Ctr Appl Math, Coll Math & Informat Sci, Guangzhou, Guangdong, Peoples R China

[9] Nanjing Agr Univ, Dept Entomol, Nanjing, Jiangsu, Peoples R China

[10] Guangdong Prov Ctr Dis Control & Prevent, Guangzhou, Guangdong, Peoples R China

[11] Chinese Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Collaborat Innovat Ctr Diag & Treatment Infect Di, Natl Inst Communicable Dis Control & Prevent, Beijing, Peoples R China

[12] Guangzhou Univ, Lingnan Stat Sci Res Inst, Guangzhou, Guangdong, Peoples R China

[13] Univ Melbourne, Bio21 Inst, Sch BioSci, Melbourne, Vic, Australia

来源：

NATURE | 2019年 / 572卷 / 7767期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

CULEX-PIPIENS-FATIGANS; CYTOPLASMIC INCOMPATIBILITY; WOLBACHIA INFECTION; ZIKA VIRUS; DIPTERA; STRAIN; DENGUE; TRANSMISSION; INTEGRATION; COMPLEX;

D O I：

10.1038/s41586-019-1407-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The radiation-based sterile insect technique (SIT) has successfully suppressed field populations of several insect pest species, but its effect on mosquito vector control has been limited. The related incompatible insect technique (IIT)-which uses sterilization caused by the maternally inherited endosymbiotic bacteria Wolbachia-is a promising alternative, but can be undermined by accidental release of females infected with the same Wolbachia strain as the released males. Here we show that combining incompatible and sterile insect techniques (IIT-SIT) enables near elimination of field populations of the world's most invasive mosquito species, Aedes albopictus. Millions of factory-reared adult males with an artificial triple-Wolbachia infection were released, with prior pupal irradiation of the released mosquitoes to prevent unintentionally released triply infected females from successfully reproducing in the field. This successful field trial demonstrates the feasibility of area-wide application of combined IIT-SIT for mosquito vector control.

引用

页码：56 / +

页数：19

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