Systematic chemoenzymatic synthesis of O-sulfated sialyl Lewis x antigens

被引：0

作者：

Santra, Abhishek ^{[1
]}

Yu, Hai ^{[1
]}

Tasnima, Nova ^{[1
]}

Muthana, Musleh M. ^{[1
]}

Li, Yanhong ^{[1
]}

Zeng, Jie ^{[1
,2
]}

Kenyon, Nicholas J. ^{[3
]}

Louie, Angelique Y. ^{[4
]}

Chen, Xi ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Chem, One Shields Ave, Davis, CA 95616 USA

[2] Henan Inst Sci & Technol, Sch Food Sci, Xinxiang 453003, Peoples R China

[3] Univ Calif Davis, Dept Internal Med, Div Pulm Crit Care & Sleep Med, Davis, CA 95616 USA

[4] Univ Calif Davis, Dept Biomed Engn, Davis, CA 95616 USA

来源：

CHEMICAL SCIENCE | 2016年 / 7卷 / 04期

关键词：

ENDOTHELIAL-DERIVED LIGAND; LE(X) GANGLIOSIDE ANALOGS; REAL CARBOHYDRATE LIGAND; MAJOR CAPPING GROUP; L-SELECTIN; SIGLEC-F; AUTOMATED SYNTHESIS; HEPARAN-SULFATE; BUILDING-BLOCK; GLYCANS;

D O I：

10.1039/c5sc04104j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

O-Sulfated sialyl Lewis x antigens play important roles in nature. However, due to their structural complexity, they are not readily accessible by either chemical or enzymatic synthetic processes. Taking advantage of a bacterial sialyltransferase mutant that can catalyze the transfer of different sialic acid forms from the corresponding sugar nucleotide donors to Lewis x antigens, which are fucosylated glycans, as well as an efficient one-pot multienzyme (OPME) sialylation system, O-sulfated sialyl Lewis x antigens containing different sialic acid forms and O-sulfation at different locations were systematically synthesized by chemoenzymatic methods.

引用

页码：2827 / 2831

页数：5

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