Synthesis of a series of vicinal diamines with potential biological activity

被引：6
|
作者：
Kurteva, V [1 ]
Lyapova, M [1 ]
机构：
[1] Bulgarian Acad Sci, Inst Organ Chem, BU-1113 Sofia, Bulgaria
来源：
CENTRAL EUROPEAN JOURNAL OF CHEMISTRY | 2004年 / 2卷 / 04期
关键词：
amino alcohols; aziridinium ion; ring opening; vicinal diamines; regioselectivity;
D O I：
10.2478/BF02482731
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A broad range of vicinal diamines based on styrene oxide are synthesised via mixtures of regioisomeric amino alcohols. The ring opening of the intermediate aziridinium ions by primary amines proceeds with high regioselectivity, leading to the target diamines as single regioisomers for all reaction series. The compounds are of potential biological interest as ligands for cisplatin analogues. Anticancer activity tests of both groups of compounds are in progress. (C) Central European Science Journals. All rights reserved.
引用
收藏
页码：686 / 695
页数：10
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