Structures of new cytotoxic antibiotics, piericidins C7 and C8

被引：19
|
作者：
Hayakawa, Yoichi
Shirasaki, Shingo
Kawasaki, Takashi
Matsuo, Yoshihide
Adachi, Kyoko
Shizuri, Yoshikazu
机构：
[1] Tokyo Univ Sci, Fac Pharmaceut Sci, Noda, Chiba 2788510, Japan
[2] Marine Biotechnol Inst Co Ltd, Kamaishi, Iwate 0260001, Japan
来源：
JOURNAL OF ANTIBIOTICS | 2007年 / 60卷 / 03期
关键词：
piericidin; cytotoxic antibiotic; epoxide;
D O I：
10.1038/ja.2007.23
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Two new cytotoxic antibiotics, piericidins C-7 (1) and C, (2), were isolated from a marine Streptomyces sp. High-resolution FAB-MS established the molecular formulae of 1 and 2 as C28H41NO5 and C29H43NO5, respectively. The planar structures of the piericidins were elucidated by NMR spectral analysis including COSY, HMQC and HMBC. The relative stereochemistry of 2 was determined based on NOESY and coupling constant analyses. 1 and 2 are new members of the piericidin family possessing 11, 12-epoxide and 12-butenyl groups.
引用
收藏
页码：201 / 203
页数：3
相关论文
共 50 条
  • [21] C7 POLYMORPHISM IN JAPANESE - NEW ALLELE C7-STAR-8
    KOMATSU, N
    KIDO, A
    OYA, M
    JAPANESE JOURNAL OF HUMAN GENETICS, 1988, 33 (02): : 278 - 278
  • [22] Surface behaviour of C5, C6, C7 and C8 lecithins at the aqueous solution/air interface
    Martínez-Landeira, P
    López-Fortán, JL
    Ruso, JM
    Prieto, G
    Sarmiento, F
    COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2003, 216 (1-3) : 91 - 96
  • [23] A novel case of multiple variations in the brachial plexus with the middle trunk originating from the C7 and C8
    Kimura, Seiichi
    Amatani, Hiromu
    Nakai, Hikaru
    Miyauchi, Ren
    Nagaoka, Tomohito
    Abe, Mikiko
    Kai, Masatake
    Yamagishi, Toshiyuki
    Nakajima, Yuji
    ANATOMICAL SCIENCE INTERNATIONAL, 2020, 95 (04) : 559 - 563
  • [24] Isomerization of C7 and C8 through Ionic Liquids Supported by a Fe/SBA-15 Catalyst
    Ramesh, Vijayalakshmi
    Perumal, Tamizhdurai
    Mangesh, V. L.
    Chandrasekaran, Kavitha
    Rajendran, Kumaran
    Kumar, Nadavala Siva
    Basivi, Praveen Kumar
    Al-Fatesh, Ahmed S.
    LANGMUIR, 2023, 39 (42) : 15107 - 15121
  • [25] SYNTHESIS OF C3, C5, C6, C7, C8, AND C9 BY HUMAN FIBROBLASTS
    GARRED, P
    HETLAND, G
    MOLLNES, TE
    STOERVOLD, G
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1990, 32 (05) : 555 - 560
  • [26] A novel case of multiple variations in the brachial plexus with the middle trunk originating from the C7 and C8
    Seiichi Kimura
    Hiromu Amatani
    Hikaru Nakai
    Ren Miyauchi
    Tomohito Nagaoka
    Mikiko Abe
    Masatake Kai
    Toshiyuki Yamagishi
    Yuji Nakajima
    Anatomical Science International, 2020, 95 : 559 - 563
  • [27] NEISSERIA-MENINGITIDIS AND NEISSERIA-GONORRHOEAE BACTEREMIA ASSOCIATED WITH C6, C7, OR C8 DEFICIENCY
    PETERSEN, BH
    LEE, TJ
    SNYDERMAN, R
    BROOKS, GF
    ANNALS OF INTERNAL MEDICINE, 1979, 90 (06) : 917 - 920
  • [28] 天然气中C6、C7、C8准确定量测试研究
    袁雨林
    天然气工业, 1998, (01) : 106 - 107
  • [29] Improved Rigidin-Inspired Antiproliferative Agents with Modifications on the 7-Deazahypoxanthine C7/C8 Ring Systems
    van der Westhuyzen, Aletta E.
    Ashraf, Naghmana
    Conradie, Daleen
    Loots, Leigh
    Kaschula, Catherine H.
    Pelly, Stephen C.
    Frolova, Liliya V.
    Landfair, Taylor
    Shuster, Charles B.
    Betancourt, Tania
    Kornienko, Alexander
    van Otterlo, Willem A. L.
    JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (12) : 9950 - 9975
  • [30] ACIDIFIED C5 PLUS C6 INITIATE A RELEASE REACTION OF LIPOSOMES WITH C7, C8 AND C9
    ROTHER, U
    RAUTERBERG, EW
    HANSCH, GM
    IMMUNOBIOLOGY, 1980, 157 (03) : 272 - 272
12345