Structures of new cytotoxic antibiotics, piericidins C7 and C8

被引：19
|
作者：
Hayakawa, Yoichi
Shirasaki, Shingo
Kawasaki, Takashi
Matsuo, Yoshihide
Adachi, Kyoko
Shizuri, Yoshikazu
机构：
[1] Tokyo Univ Sci, Fac Pharmaceut Sci, Noda, Chiba 2788510, Japan
[2] Marine Biotechnol Inst Co Ltd, Kamaishi, Iwate 0260001, Japan
来源：
JOURNAL OF ANTIBIOTICS | 2007年 / 60卷 / 03期
关键词：
piericidin; cytotoxic antibiotic; epoxide;
D O I：
10.1038/ja.2007.23
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Two new cytotoxic antibiotics, piericidins C-7 (1) and C, (2), were isolated from a marine Streptomyces sp. High-resolution FAB-MS established the molecular formulae of 1 and 2 as C28H41NO5 and C29H43NO5, respectively. The planar structures of the piericidins were elucidated by NMR spectral analysis including COSY, HMQC and HMBC. The relative stereochemistry of 2 was determined based on NOESY and coupling constant analyses. 1 and 2 are new members of the piericidin family possessing 11, 12-epoxide and 12-butenyl groups.
引用
收藏
页码：201 / 203
页数：3
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