Seeing the future of bioactive lipid drug targets

被引:13
|
作者
Evans, Jilly F. [1 ]
Hutchinson, John H. [1 ]
机构
[1] Amira Pharmaceut, San Diego, CA USA
关键词
NUCLEAR RECEPTORS; DISEASES; INFLAMMATION; DISCOVERY; LESSONS; LIGAND; LUNG;
D O I
10.1038/nchembio.394
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Bioactive lipid signaling allows individual cells within the body to 'see' the surrounding environment and to respond in ways that will benefit the whole organism. Successful drug development for bioactive lipid targets requires a deep knowledge of the biology and pathobiology of each specific lipid signaling pathway.
引用
收藏
页码:476 / 479
页数:4
相关论文
共 50 条
  • [21] Drug repurposing: mining protozoan proteomes for targets of known bioactive compounds
    Sateriale, Adam
    Bessoff, Kovi
    Sarkar, Indra Neil
    Huston, Christopher D.
    JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION, 2014, 21 (02) : 238 - 244
  • [22] Future drug targets for Parkinson's disease DISCUSSION
    Rondot, Pierre
    Costentin, Jean
    Cabanis, Emmanuel Alain
    Godeau, Pierre
    Dufier, Jean-Louis
    Chouard, Claude-Henri
    Sraer, Jean-Daniel
    Hauw, Jean-Jacques
    BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE, 2012, 196 (07): : 1377 - 1379
  • [23] Neuropathic pain: Drug targets for current and future interventions
    Smith, PA
    DRUG NEWS & PERSPECTIVES, 2004, 17 (01) : 5 - 17
  • [24] Molecular modelling of drug targets: The past, the present and the future
    Dahl, SG
    Sylte, I
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2005, 96 (03) : 151 - 155
  • [25] The Future of Medicinal Chemistry, PROTAC, and Undruggable Drug Targets
    Poso, Antti
    JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (15) : 10680 - 10681
  • [26] Tuberculosis: current scenario, drug targets, and future prospects
    Priyanka Bose
    Amit K. Harit
    Ratnesh Das
    Samaresh Sau
    Arun K. Iyer
    Sushil K. Kashaw
    Medicinal Chemistry Research, 2021, 30 : 807 - 833
  • [27] Tuberculosis: current scenario, drug targets, and future prospects
    Bose, Priyanka
    Harit, Amit K.
    Das, Ratnesh
    Sau, Samaresh
    Iyer, Arun K.
    Kashaw, Sushil K.
    MEDICINAL CHEMISTRY RESEARCH, 2021, 30 (04) : 807 - 833
  • [28] Prophylaxis of hepatic encephalopathy: current and future drug targets
    Maharshi, Sudhir
    Sharma, Barjesh Chander
    HEPATOLOGY INTERNATIONAL, 2024, 18 (04) : 1096 - 1109
  • [29] The Future of Antifungal Drug Therapy: Novel Compounds and Targets
    Fernandes, Caroline Mota
    Dasilva, Deveney
    Haranahalli, Krupanandan
    McCarthy, J. Brian
    Mallamo, John
    Ojima, Iwao
    Del Poeta, Maurizio
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021, 65 (02)
  • [30] Drug targets for resistant malaria: Historic to future perspectives
    Kumar, Sahil
    Bhardwaj, T. R.
    Prasad, D. N.
    Singh, Rajesh K.
    BIOMEDICINE & PHARMACOTHERAPY, 2018, 104 : 8 - 27