Lymphatic Dysregulation in Patients With Heart Failure JACC Review Topic of the Week

The lymphatic system is an integral part of the circulatory system and plays an important rote in the volume homeostasis of the human body. The complex anatomy and physiology paired with a tack of simple diagnostic toots to study the lymphatic system have led to an underappreciation of the contribution of the lymphatic system to acute and chronic heart failure (HF). Herein, we discuss the physiological rote of the lymphatic system in volume management and the evidence demonstrating the dysregulation of the lymphatic system in HF. Further, we discuss the opportunity to target the lymphatic system in the management of HF and different potential approaches to accessing the lymphatic system. (C) 2021 by the American College of Cardiology Foundation.