Descriptive Comparisons of the Effect of Apremilast and Methotrexate Monotherapy in Oligoarticular Psoriatic Arthritis: The Corrona Psoriatic Arthritis/Spondyloarthritis Registry Results

被引：8

作者：

Ogdie, Alexis ^{[1
,2
]}

Liu, Mei ^{[3
]}

Glynn, Meghan ^{[3
]}

Emeanuru, Kelechi ^{[3
]}

Harrold, Leslie R. ^{[4
]}

Richter, Sven ^{[5
]}

Guerette, Benoit ^{[5
]}

Mease, Philip J. ^{[6
,7
]}

机构：

[1] Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Perelman Sch Med, Dept Epidemiol, Philadelphia, PA 19104 USA

[3] Corrona LLC, Waltham, MA USA

[4] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA USA

[5] Amgen Inc, Global Med Affairs, Thousand Oaks, CA 91320 USA

[6] Univ Washington, Sch Med, Div Rheumatol Clin Res, Swedish Med Ctr,Providence St Joseph Hlth, Seattle, WA USA

[7] Univ Washington, Sch Med, Div Rheumatol, Seattle, WA USA

来源：

JOURNAL OF RHEUMATOLOGY | 2021年 / 48卷 / 05期

关键词：

arthritis; methotrexate; psoriatic arthritis; TNF receptors; RECOMMENDATIONS; DISEASE; PSA;

D O I：

10.3899/jrheum.191209

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. Therapeutic response was evaluated among new apremilast, methotrexate (MTX), or biologic disease-modifying antirheumatic drug (bDMARD) initiators with oligoarticular psoriatic arthritis (PsA). Methods. Patients with oligoarticular PsA in the Corrona PsA/Spondyloarthritis Registry initiating treatment with apremilast, MTX, or bDMARD, and completing 6-month follow-up were included. Results. In total, 150 patients initiated rnonotherapy (aprernilast: n = 34; MTX: n = 15; bDMARD: n = 101). Apremilast initiators had higher baseline disease activity than MTX initiators. At follow-up, apremilast initiators experienced numerically greater disease activity improvements than MTX initiators and similar improvements to bDMARD initiators. Conclusion. Findings suggest aprernilast monotherapy is an effective option for patients with oligoarticular PsA.

引用

页码：693 / 697

页数：5

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