Benzoquinones from Ardisia japonica with inhibitory activity towards human protein tyrosine phosphatase 1B (PTP1B)

被引：11
|
作者：
Li, Yan-Fang
Li, Jia
Shen, Qiang
Hu, Li-Hong [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China
[2] Sichuan Univ, Dept Pharmaceut & Bioengn, Chengdu 610065, Peoples R China
[3] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
来源：
CHEMISTRY & BIODIVERSITY | 2007年 / 4卷 / 05期
关键词：
D O I：
10.1002/cbdv.200790086
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
From the whole plant of Ardisia japonica, four [1,4]benzoquinones were isolated by means of bioassay-directed fractionation of the EtOH extract. Apart from the two known compounds maesanin (1) and its congener 2, two new benzoquinones, i.e., 5-ethoxy-2-hydroxy-3-[(10Z)-pentadec-10-en-1-yl][1,4]benzoquinone (3) and 5-ethoxy-2-hydroxy-3-[(8Z)-tridec-8-en-1-yl] [ 1,4] benzoquinone (4), were identified. All compounds showed significant in vitro bioactivities against the PTP1B enzyme, with IC50 values in the range of ca. 3 - 19 mu m.
引用
收藏
页码：961 / 965
页数：5
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