Rhodium(III)-Catalyzed Intermolecular Hydroarylation of Alkynes

被引：273

作者：

Schipper, Derek J. ^{[1
]}

Hutchinson, Marieke ^{[1
]}

Fagnou, Keith ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem, Ctr Catalysis Res & Innovat, Ottawa, ON K1N 6N5, Canada

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 20期

基金：

加拿大自然科学与工程研究理事会;

关键词：

C-H ACTIVATION; CATALYZED DIRECT ARYLATION; CARBON-HYDROGEN BONDS; INTERNAL ALKYNES; SIMPLE ARENES; FUNCTIONALIZATION; CLEAVAGE; MECHANISM; 2-PHENYLPYRIDINES; ALKENYLATION;

D O I：

10.1021/ja103080d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The rhodium(III)-catalyzed hydroarylation of internal alkynes is described. Good yields are obtained for a variety of alkynes, and excellent regioselectivity is observed for unsymmetrically substituted alkynes. The reaction also gives good yields for a range of arenes. Preliminary mechanistic investigations suggest that this reaction proceeds through arene metalation with the cationic rhodium catalyst, which enables challenging intermolecular reactivity.

引用

页码：6910 / +

页数：3

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