Model predicting the ypN0 status after good response to chemoradiotherapy in rectal cancer

被引：3
|
作者：
Dumont, E. [1 ]
Dartigues, P. [2 ]
Delga, B. [1 ]
Thibaudeau, E. [1 ]
Benhaim, L. [3 ]
Campion, L. [4 ]
Mosnier, J. F. [5 ]
Raimbourg, J. [6 ]
Kerdraon, O. [7 ]
Goere, D. [3 ]
机构：
[1] West Oncol Inst, Dept Digest Oncol Surg, St Herblain, France
[2] Gustave Roussy Canc Campus, Dept Pathol, Villejuif, France
[3] Gustave Roussy Canc Campus, Dept Digest Oncol Surg, Villejuif, France
[4] West Oncol Inst, Dept Stat, St Herblain, France
[5] Univ Hosp, Dept Pathol, Nantes, France
[6] West Oncol Inst, Dept Oncol, St Herblain, France
[7] West Oncol Inst, Dept Pathol, St Herblain, France
来源：
AMERICAN JOURNAL OF SURGERY | 2018年 / 216卷 / 03期
关键词：
Rectal cancer; Chemoradiotherapy; Nodal staging; Lymph node; Chemoradiotherapy T status; Good response; PATHOLOGICAL COMPLETE RESPONSE; LYMPH-NODE METASTASES; PREOPERATIVE CHEMORADIATION; NEOADJUVANT CHEMORADIOTHERAPY; RANDOMIZED-TRIAL; LOCAL EXCISION; METAANALYSIS; CARCINOMA; THERAPY; OXALIPLATIN;
D O I：
10.1016/j.amjsurg.2018.03.025
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Background: The purpose of this study was to identify the predictive factors for ypN0 status in tumors with good pathologic response to chemoradiotherapy (CRT). Methods: A retrospective chart review was conducted on patients at two tertiary cancer center who underwent rectal resection after good response to CRT between 2000 and 2013. Results: No preoperative treatment (oxaliplatin use, radiotherapy boost of 5,4 Gy, delay CRT-surgery) impacted on the ypN status. In the multivariate analysis, only a ypT<3 (HR 7.5 [2,9-19.5]) was significant and no lymphovascular invasion (HR 8,9 [1.6-49.8]) was limited to significance.The best model predicting the ypN0 status used only the ypT status<3. The major part (92.2%) of patients with ypT0-2 tumors had no LN invasion. Conclusion: The risk of lymph node involvement metastases was only 7.8% for the patients with an ypT0-2 status. A fullthickness transanal resection coud be the futur treatment of these patients. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码：438 / 443
页数：6
相关论文
共 50 条
  • [21] Omission of axillary irradiation in breast cancer patients with ypN0 after neoadjuvant chemotherapy
    Sarandao, S.
    Fernandes, F.
    Costa, S.
    Rodrigues, J.
    Azevedo, I.
    Pereira, H.
    RADIOTHERAPY AND ONCOLOGY, 2021, 161 : S936 - S937
  • [22] ypN0 in Patients With Definitive cN-positive Status After Preoperative Treatment Is a Prognostic Factor in Esophageal Cancer
    Yoshida, Takahiro
    Nishino, Takeshi
    Goto, Masakazu
    Inoue, Seiya
    Fujiwara, Satoshi
    Takizawa, Hiromitsu
    Tangoku, Akira
    Uehara, Hisanori
    Bando, Yoshimi
    ANTICANCER RESEARCH, 2022, 42 (01) : 195 - 203
  • [23] Postoperative chemotherapy may not be necessary for patients with ypN0-category after neoadjuvant chemoradiotherapy of rectal cancer
    Fietkau, Rainer
    Barten, Malte
    Klautke, Gunther
    Klar, Ernst
    Ludwig, Kaja
    Thomas, Hartmut
    Brinckmann, Wolfgang
    Friedrich, Andreas
    Prall, Friedrich
    Hartung, Gernot
    Kuechenmeister, Ute
    Kundt, Gunther
    DISEASES OF THE COLON & RECTUM, 2006, 49 (09) : 1284 - 1292
  • [24] Nodal Downstaging in Gastric Cancer: Promising Survival if ypN0 Is Achieved
    Ikoma, N.
    Estrella, J.
    Hofstetter, W.
    Das, P.
    Ajani, J.
    Fournier, K.
    Mansfield, P.
    Badgwell, B.
    ANNALS OF SURGICAL ONCOLOGY, 2018, 25 : S7 - S7
  • [25] Impact of adjuvant chemotherapy on patients with ypT0-2 ypN0 rectal cancer after neoadjuvant chemoradiation: a cohort study from a tertiary referral hospital
    Galata, Christian
    Merx, Kirsten
    Mai, Sabine
    Gaiser, Timo
    Wenz, Frederik
    Post, Stefan
    Kienle, Peter
    Hofheinz, Ralf-Dieter
    Horisberger, Karoline
    WORLD JOURNAL OF SURGICAL ONCOLOGY, 2018, 16
  • [26] Nodal Downstaging in Gastric Cancer Patients: Promising Survival if ypN0 is Achieved
    Ikoma, Naruhiko
    Estrella, Jeannelyn S.
    Hofstetter, Wayne
    Das, Prajnan
    Minsky, Bruce D.
    Ajani, Jaffer A.
    Fournier, Keith F.
    Mansfield, Paul
    Badgwell, Brian D.
    ANNALS OF SURGICAL ONCOLOGY, 2018, 25 (07) : 2012 - 2017
  • [27] Impact of adjuvant chemotherapy on patients with ypT0–2 ypN0 rectal cancer after neoadjuvant chemoradiation: a cohort study from a tertiary referral hospital
    Christian Galata
    Kirsten Merx
    Sabine Mai
    Timo Gaiser
    Frederik Wenz
    Stefan Post
    Peter Kienle
    Ralf-Dieter Hofheinz
    Karoline Horisberger
    World Journal of Surgical Oncology, 16
  • [28] Nodal downstaging in gastric cancer in relation to survival when ypN0 is achieved
    Ikoma, Naruhiko
    Estrella, Jeannelyn
    Hofstetter, Wayne Lewis
    Das, Prajnan
    Ajani, Jaffer A.
    Fournier, Keith F.
    Mansfield, Paul F.
    Badgwell, Brian D.
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (04)
  • [29] Nodal Downstaging in Gastric Cancer Patients: Promising Survival if ypN0 is Achieved
    Naruhiko Ikoma
    Jeannelyn S. Estrella
    Wayne Hofstetter
    Prajnan Das
    Bruce D. Minsky
    Jaffer A. Ajani
    Keith F. Fournier
    Paul Mansfield
    Brian D. Badgwell
    Annals of Surgical Oncology, 2018, 25 : 2012 - 2017
  • [30] Predicting response to chemoradiotherapy in rectal cancer: are we there yet?
    Lindsey, Ian
    COLORECTAL DISEASE, 2013, 15 (10) : 1199 - 1200
12345