A New Isophthalic Acid from Talaromyces flavus

被引：0
|
作者：
He, Junwei [1 ]
Yang, Li [1 ]
Wang, Yaqi [1 ]
Mu, Zhengqiang [2 ]
Zou, Zhengrong [3 ]
Wang, Xiumei [1 ]
Zhong, Guoyue [1 ]
机构：
[1] Jiangxi Univ Tradit Chinese Med, Nanchang 330004, Jiangxi, Peoples R China
[2] Sichuan Univ Sci & Engn, Sch Chem Engn, Zigong 643000, Peoples R China
[3] Jiangxi Normal Univ, Coll Life Sci, Jiangxi Prov Key Lab Protect & Utilizat Subtrop P, Nanchang 330004, Jiangxi, Peoples R China
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2017年 / 53卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Talaromyces flavus; isophthalic acid; anti-A beta(42) aggregation activity;
D O I：
10.1007/s10600-017-2010-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new isophthalic acid, 2-acetyl-5-hydroxy-6-methoxyisophthalic acid (1), was isolated from the wetland soil-derived fungus Talaromyces flavus (No. BYD07-13). Its chemical structure was elucidated on the basis of UV, IR, MS, and NMR spectroscopic analyses. The anti-A beta (42) aggregation, cytotoxic, and antimicrobial activities of compound 1 were tested. Compound 1 displayed significant anti-A beta (42) aggregation activity with a relative inhibitory rate value of 55.01% at a concentration of 100 mu mol/mL. This is the first report that isophthalic acid has anti-A beta (42) agregation activity.
引用
收藏
页码：409 / 411
页数：3
相关论文
共 50 条
  • [21] Purification and partial characterization of two chitinases from the mycoparasitic fungus Talaromyces flavus
    Duo-Chuan, LI
    Chen, S
    Jing, LU
    MYCOPATHOLOGIA, 2005, 159 (02) : 223 - 229
  • [22] ISOPHTHALIC ACID
    HARA, H
    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 1987, 45 (04) : 393 - 393
  • [23] TALAROMYCES FLAVUS, A RARE BUT FATAL NON-MARNEFFEI TALAROMYCES IN PATIENT WITH PERITONEAL DIALYSIS
    Sookto, Phanit
    Kanjanabuch, Talerngsak
    Chamroensakchai, Tamonwan
    Thongbor, Nisa
    Eiam-Ong, Somchai
    NEPHROLOGY, 2021, 26 : 43 - 43
  • [24] A set of interesting sequoiatones stereoisomers from awetlandsoil-derivedfungus Talaromyces flavus
    Sun, Tianyu
    Zou, Jian
    Chen, Guodong
    Hu, Dan
    Wu, Bin
    Liu, Xingzhong
    Yao, Xinsheng
    Gao, Hao
    ACTA PHARMACEUTICA SINICA B, 2017, 7 (02) : 167 - 172
  • [25] Purification and partial characterization of two chitinases from the mycoparasitic fungus Talaromyces flavus
    L.I. Duo-Chuan
    Shu Chen
    L.U. Jing
    Mycopathologia, 2005, 159 : 223 - 229
  • [26] ISOPHTHALIC ACID
    DERISSEN, JL
    ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1974, 30 (NOV15): : 2764 - 2765
  • [27] HEAT ACTIVATION OF DORMANT ASCOSPORES OF TALAROMYCES-FLAVUS
    KATAN, T
    TRANSACTIONS OF THE BRITISH MYCOLOGICAL SOCIETY, 1985, 84 (JUN): : 748 - 750
  • [28] COMPATIBILITY OF TALAROMYCES-FLAVUS WITH POTATO SEEDPIECE FUNGICIDES
    FRAVEL, DR
    MAROIS, JJ
    DUNN, MT
    PAPAVIZAS, GC
    SOIL BIOLOGY & BIOCHEMISTRY, 1985, 17 (02): : 163 - 166
  • [29] Biodegradation of nicosulfuron by a Talaromyces flavus LZM1
    Song, Jinlong
    Gu, Jingang
    Zhai, Yi
    Wu, Wei
    Wang, Haisheng
    Ruan, Zhiyong
    Shi, Yanhua
    Yan, Yanchun
    BIORESOURCE TECHNOLOGY, 2013, 140 : 243 - 248
  • [30] HYPERPARASITISM OF SCLEROTINIA-SCLEROTIORUM BY TALAROMYCES-FLAVUS
    MCLAREN, DL
    HUANG, HC
    RIMMER, SR
    CANADIAN JOURNAL OF PLANT PATHOLOGY-REVUE CANADIENNE DE PHYTOPATHOLOGIE, 1986, 8 (01): : 43 - 48
12345