A New Isophthalic Acid from Talaromyces flavus

被引：0
|
作者：
He, Junwei [1 ]
Yang, Li [1 ]
Wang, Yaqi [1 ]
Mu, Zhengqiang [2 ]
Zou, Zhengrong [3 ]
Wang, Xiumei [1 ]
Zhong, Guoyue [1 ]
机构：
[1] Jiangxi Univ Tradit Chinese Med, Nanchang 330004, Jiangxi, Peoples R China
[2] Sichuan Univ Sci & Engn, Sch Chem Engn, Zigong 643000, Peoples R China
[3] Jiangxi Normal Univ, Coll Life Sci, Jiangxi Prov Key Lab Protect & Utilizat Subtrop P, Nanchang 330004, Jiangxi, Peoples R China
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2017年 / 53卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Talaromyces flavus; isophthalic acid; anti-A beta(42) aggregation activity;
D O I：
10.1007/s10600-017-2010-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new isophthalic acid, 2-acetyl-5-hydroxy-6-methoxyisophthalic acid (1), was isolated from the wetland soil-derived fungus Talaromyces flavus (No. BYD07-13). Its chemical structure was elucidated on the basis of UV, IR, MS, and NMR spectroscopic analyses. The anti-A beta (42) aggregation, cytotoxic, and antimicrobial activities of compound 1 were tested. Compound 1 displayed significant anti-A beta (42) aggregation activity with a relative inhibitory rate value of 55.01% at a concentration of 100 mu mol/mL. This is the first report that isophthalic acid has anti-A beta (42) agregation activity.
引用
收藏
页码：409 / 411
页数：3
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