Copper-catalyzed C(sp3)-H/N-H Cross Dehydrogenative Coupling Between Toluene Derivatives and Picolinamides

被引：1
|
作者：
Ji, Huihui [1 ]
Zhan, Hongju [2 ]
Chen, Shumin [2 ]
Fang, Zeguo [1 ]
Zhang, Qian [1 ]
Li, Dong [1 ,2 ]
机构：
[1] Hubei Univ Technol, New Mat & Green Mfg Talent Intro & Innovat Demons, Sch Mat & Chem Engn, Wuhan 430068, Peoples R China
[2] Jingchu Univ Technol, Hubei Prov Key Lab Drug Synth & Optimizat, Jingmen 448000, Peoples R China
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 11卷 / 10期
关键词：
amidation; benzylic C-H bond; copper; cross dehydrogenative coupling; toluene; C-H AMINATION; BOND FORMATION; INTRAMOLECULAR AMINATION; BENZYLIC HYDROCARBONS; CARBOXYLIC-ACIDS; N-METHYLATION; SIMPLE ETHERS; AMIDATION; FUNCTIONALIZATION; AMIDES;
D O I：
10.1002/ajoc.202200454
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient C-N bond formation method through copper-catalyzed C(sp3)-H/N-H cross dehydrogenative coupling between toluene derivatives and picolinamides was developed. The N-H bond of picolinamides was activated by the direction of pyridyl group without influence of remote C-H bonds. The method was applicable to a broad range of substrates with good functional group compatibility, which provided a novel route to prepare N-benzyl tertiary amides from cheap and readily available starting materials.
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页数：5
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