New macrocyclic polyether compounds containing a 2,5-bis(2-hydroxypheny1)-1,3,4-oxadiazole moiety are quickly prepared by a nucleophilic substitution reaction involving ethylene glycol ditosylate or polyethylene glycol ditosylate and a biphenol, the 2,5-bis(2-hydroxyphenyl)-1,34-oxadiazole, with solid anhydrous potassium carbonate as a base under microwave irradiation (monomode and multimode). The structures of new macrocyclic polyether compounds were confirmed by (1)H, (13)C NMR, mass spectrometry, and elemental analysis.