High-Fat Diet Augments Ovariectomy-Induced Bone Resorption in Rats

被引：0
|
作者：
El-Bidawy, Mahmoud H. [1 ,2 ]
Bastawy, Nermeen [2 ]
Khalifa, Mohamed Mansour [2 ,3 ]
Abdulla, Hanan [4 ]
Elsayed, Rania [5 ]
Rashed, Laila [5 ]
Niazy, Marwa [6 ]
Al-Ghamdi, Sameer [7 ]
Haidara, Mohamed A. [8 ]
机构：
[1] Prince Sattam Ibn Abdulaziz Univ, Dept BMS, Coll Med, Div Physiol, Al Kharj, Saudi Arabia
[2] Cairo Univ, Fac Med, Dept Med Physiol, Giza, Egypt
[3] King Saud Univ, Coll Med, Dept Physiol, Rihadah, Saudi Arabia
[4] Fac Med, Histol & Cell Biol, Giza, Egypt
[5] Cairo Univ, Fac Med, Biochem, Giza, Egypt
[6] Cairo Univ, Fac Med, Rheumatol & Rehabil, Giza, Egypt
[7] Prince Sattam Ibn Abdulaziz Univ, Coll Med, Div Family Med, Al Kharj, Saudi Arabia
[8] King Khalid Univ, Coll Med, Dept Physiol, Abha 61421, Saudi Arabia
来源：
INTERNATIONAL JOURNAL OF MORPHOLOGY | 2020年 / 38卷 / 01期
关键词：
Ovariectomy; Menopause; Inflammation; NF-kB; Dyslipidemia; Rat model; NF-KAPPA-B; OSTEOPOROSIS; GLUCOSE;
D O I：
10.4067/S0717-95022020000100129
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Menopause complications such as cardiovascular and bone diseases represent a major public health concern. We sought to determine whether a high-fat diet (HFD) can augment ovariectomy-induced bone resorption in a rat model of menopause possibly via the upregulation of the inflammatory biomarkers and dyslipidemia. Rats were either ovariectomized and fed a standard laboratory chow (model group) or were ovariectomized and fed with a HFD for 15 weeks before being sacrificed. Ovariectomy significantly (p<0.05) increased body weight, dyslipidemia, insulin resistance, pro-inflammatory cytokines tumor necrosis factor-a (TNF-alpha) and interleukin-6 (IL-6), and biomarker of bone resorption, nuclear factor-kB (NF-kB), which were augmented by feeding animals with a HFD. This was confirmed through immunohistochemical study, where ovariectomy induced expression of p65/NF-kB protein in tibia bone sections of the model group, which were augmented by HFD. HFD augments ovariectomy-induced bone resorption through increased inflammatory biomarkers and NF-kB in rats.
引用
收藏
页码：129 / 134
页数：6
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