The Role of Transient Receptor Potential Vanilloid 1 in Common Diseases of the Digestive Tract and the Cardiovascular and Respiratory System

被引：85
|
作者：
Du, Qian [1 ]
Liao, Qiushi [1 ]
Chen, Changmei [1 ]
Yang, Xiaoxu [1 ]
Xie, Rui [1 ]
Xu, Jingyu [1 ]
机构：
[1] Zunyi Med Univ, Affiliated Hosp, Dept Gastroenterol, Zunyi, Peoples R China
来源：
FRONTIERS IN PHYSIOLOGY | 2019年 / 10卷
基金：
中国国家自然科学基金;
关键词：
transient receptor potential vanilloid 1; digestive tract; cardiovascular system; respiratory system; functional dyspepsia; irritable bowel syndrome; ISCHEMIA-REPERFUSION INJURY; GENE-RELATED PEPTIDE; TRP CHANNELS; VISCERAL HYPERSENSITIVITY; NEUROGENIC PANCREATITIS; CAPSAICIN TREATMENT; AFFERENT NERVES; SENSORY NEURONS; PROTECTS MICE; UP-REGULATION;
D O I：
10.3389/fphys.2019.01064
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely expressed in sensory nerve fibers and nonneuronal cells, including certain vascular endothelial cells and smooth muscle cells. The activation of TRPV1 may be involved in the regulation of various physiological functions, such as the release of inflammatory mediators in the body, gastrointestinal motility function, and temperature regulation. In recent years, a large number of studies have revealed that TRPV1 plays an important role in the physiological and pathological conditions of the digestive system, cardiovascular system, and respiratory system, but there is no systematic report on TRPV1. The objective of this review is to explain the function and effects of TRPV1 on specific diseases, such as irritable bowel syndrome, hypertension, and asthma, and to further investigate the intrinsic relationship between the expression and function of TRPV1 in those diseases to find new therapeutic targets for the cure of related diseases.
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页数：17
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