The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway

被引:189
|
作者
Pray-Grant, MG
Schieltz, D
McMahon, SJ
Wood, JM
Kennedy, EL
Cook, RG
Workman, JL
Yates, JR
Grant, PA
机构
[1] Univ Virginia, Hlth Syst, Sch Med, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA
[2] Torrey Mesa Res Inst, San Diego, CA 92121 USA
[3] Baylor Coll Med, Dept Immunol, Houston, TX 77030 USA
[4] Penn State Univ, Howard Hughes Med Inst, University Pk, PA 16802 USA
[5] Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA
[6] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA
关键词
D O I
10.1128/MCB.22.24.8774-8786.2002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The SAGA complex is a conserved histone acetyltransferase-coactivator that regulates gene expression in Saccharomyces cerevisiae. SAGA contains a number of subunits known to function in transcription including Spt and Ada proteins, the Gcn5 acetyltransferase, a subset of TATA-binding-protein-associated factors (TAF(II)s), and Tra1. Here we report the identification of SLIK (SAGA-like), a complex related in composition to SAGA. Notably SLIK uniquely contains the protein Rtg2, linking the function of SLIK to the retrograde response pathway. Yeast harboring mutations in both SAGA and SLIK complexes displays synthetic phenotypes more severe than those of yeast with mutation of either complex alone. We present data indicating that distinct forms of the SAGA complex may regulate specific subsets of genes and that SAGA and SLIK have multiple partly overlapping activities, which play a critical role in transcription by RNA polymerase II.
引用
收藏
页码:8774 / 8786
页数:13
相关论文
共 50 条
  • [31] The novel functions of the TFTC/STAGA HAT complex in histone deubiquitination dependent chromatin remodelling and transcription activation
    Zhao, Y.
    Nagy, Z.
    Lang, G.
    Ito, S.
    Bonnet, J.
    Sawatsubashi, S.
    Suzuki, E.
    Li, Y.
    Han, J.
    Takeyama, K. -I.
    Kato, S.
    Devys, D.
    Tora, L.
    FEBS JOURNAL, 2008, 275 : 29 - 29
  • [32] A Novel Sit4 Phosphatase Complex Is Involved in the Response to Ceramide Stress in Yeast
    Woodacre, Alexandra
    Lone, Museer A.
    Jablonowski, Daniel
    Schneiter, Roger
    Giorgini, Flaviano
    Schaffrath, Raffael
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2013, 2013
  • [33] Crosstalk between NSL Histone Acetyltransferase and MLL/SET Complexes: NSL Complex Functions in Promoting Histone H3K4 Di-Methylation Activity by MLL/SET Complexes
    Zhao, Xiaoming
    Su, Jiaming
    Wang, Fei
    Liu, Da
    Ding, Jian
    Yang, Yang
    Conaway, Joan W.
    Conaway, Ronald C.
    Cao, Lingling
    Wu, Donglu
    Wu, Min
    Cai, Yong
    Jin, Jingji
    PLOS GENETICS, 2013, 9 (11):
  • [34] The COG Complex, Rab6 and COPI Define a Novel Golgi Retrograde Trafficking Pathway that is Exploited by SubAB Toxin
    Smith, Richard D.
    Willett, Rose
    Kudlyk, Tetyana
    Pokrovskaya, Irina
    Paton, Adrienne W.
    Paton, James C.
    Lupashin, Vladimir V.
    TRAFFIC, 2009, 10 (10) : 1502 - 1517
  • [35] Histone H4 dosage modulates DNA damage response in the pathogenic yeast Candida glabrata via homologous recombination pathway
    Kumar, Kundan
    Moirangthem, Romila
    Kaur, Rupinder
    PLOS GENETICS, 2020, 16 (03):
  • [36] The G beta gamma complex of the yeast pheromone response pathway - Subcellular fractionation and protein-protein interactions
    Hirschman, JE
    DeZutter, GS
    Simonds, WF
    Jenness, DD
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (01) : 240 - 248
  • [37] The yeast SAS (something about silencing) protein complex contains a MYST-type putative acetyltransferase and functions with chromatin assembly factor ASF1
    Osada, S
    Sutton, A
    Muster, N
    Brown, CE
    Yates, JR
    Sternglanz, R
    Workman, JL
    GENES & DEVELOPMENT, 2001, 15 (23) : 3155 - 3168
  • [38] IBD2, a novel component of the spindle checkpoint in budding yeast, functions in BUB2 pathway.
    Hwang, HS
    Song, KW
    YEAST, 2001, 18 : S183 - S183
  • [39] A basic helix-loop-helix-leucine zipper transcription complex in yeast functions in a signaling pathway from mitochondria to the nucleus
    Jia, YK
    Rothermel, B
    Thornton, J
    Butow, RA
    MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (03) : 1110 - 1117
  • [40] Structure-based molecular design for thermostabilization of N-acetyltransferase Mpr1 involved in a novel pathway of L-arginine synthesis in yeast
    Nasuno, Ryo
    Hirase, Saeka
    Norifune, Saki
    Watanabe, Daisuke
    Takagi, Hiroshi
    JOURNAL OF BIOCHEMISTRY, 2016, 159 (02): : 271 - 277