Direct Synthesis of Enolizable N-Sulfonyl Ketimines Under Microwave Irradiation

被引：7
|
作者：
Ortiz, Pablo [1 ]
Collados, Juan F. [1 ]
Harutyunyan, Syuzanna R. [1 ]
机构：
[1] Univ Groningen, Stratingh Inst Chem, Nijenborgh 4, NL-9747 AG Groningen, Netherlands
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 2016卷 / 07期
关键词：
Microwave chemistry; Imines; Ketimines; Condensation reactions; SOLVENT-FREE SYNTHESIS; ASYMMETRIC 3+2 CYCLOADDITION; ENANTIOSELECTIVE CONSTRUCTION; STRECKER REACTION; IMINES; EFFICIENT; TRIMETHYLENEMETHANE; HYDROGENATION; PYRROLIDINES; ALDIMINES;
D O I：
10.1002/ejoc.201600022
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
N-sulfonyl imines are widely used as substrates for a range of transformations. Access to N-sulfonyl aldimines is straightforward through direct condensation between the parent aldehyde and the sulfonamide. However, this approach is not efficient for the synthesis of enolizable N-sulfonyl ketimines. Herein we report a rapid and facile methodology for obtaining these products using microwave irradiation.
引用
收藏
页码：1247 / 1250
页数：4
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