Polyacrylic resins regulate transcriptional control of interleukin-6, gp80, and gp130 genes in human gingival fibroblasts

被引：7

作者：

Borelli, Bruna ^{[1
]}

Zarone, Fernando ^{[1
]}

Rivieccio, Virginia ^{[1
]}

Riccitiello, Francesco ^{[1
]}

Simeone, Michele ^{[1
]}

Sorrentino, Roberto ^{[1
]}

Rengo, Sandro ^{[1
]}

Spagnuolo, Gianrico ^{[1
]}

Procino, Alfredo ^{[1
]}

机构：

[1] Univ Naples Federico II, Med Sch, Dept Neurosci Reprod & Odontostomatol Sci, Via S Pansini 5, I-80131 Naples, Italy

来源：

JOURNAL OF ORAL SCIENCE | 2017年 / 59卷 / 01期

关键词：

inflammation; interleukin-6; cytotoxicity; cell culture; cytokines; C-REACTIVE PROTEIN; CARDIOVASCULAR MORTALITY; RELEASE; PREDICTION; CYTOKINES; POLYMERS; NECROSIS; DISEASE; CELLS; WOMEN;

D O I：

10.2334/josnusd.16-0388

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Studies have failed to identify the molecular mechanisms that regulate the genotoxic and cytotoxic effects of methacrylate resins, which are important in the biocompatibility of dental materials. Interleukin (IL)-6 has a crucial role in the control of acute-phase protein response during inflammation. In humans, the synthesis and release of two major acute-phase proteins, C-reactive protein and serum amyloid A, are regulated by IL-6. This study focused on IL-6 and activation of its receptors gp80 and gp130 in human gingival fibroblasts in order to assess the effects of the commercial acid resins Jet Kit, Unifast, and Duralay on control of inflammation.

引用

页码：87 / 91

页数：5

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